Zinc finger CCCH-type containing 12A (Q21108146)

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mammalian protein found in Homo sapiens

MCP-1 treatment-induced protein
ribonuclease ZC3H12A
monocyte chemotactic protein-induced protein 1
endoribonuclease ZC3H12A
MCP-induced protein 1
zinc finger CCCH domain-containing protein 12A
regnase-1
ZC3H12A
bifunctional endoribonuclease and deubiquitinase ZC3H12A

Language	Label	Description	Also known as
English	Zinc finger CCCH-type containing 12A	mammalian protein found in Homo sapiens	MCP-1 treatment-induced protein ribonuclease ZC3H12A monocyte chemotactic protein-induced protein 1 endoribonuclease ZC3H12A MCP-induced protein 1 zinc finger CCCH domain-containing protein 12A regnase-1 ZC3H12A bifunctional endoribonuclease and deubiquitinase ZC3H12A

Statements

1 reference

13 November 2019

UniProt protein ID

Ribonuclease Zc3h12a-like, NYN domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

1 reference

8 April 2019

MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

chromatin binding

determination method

1 reference

8 April 2019

Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

ribonuclease activity

determination method

1 reference

8 April 2019

MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

protein binding

determination method

8 references

8 April 2019

Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

A directed protein interaction network for investigating intracellular signal transduction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

endonuclease activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

determination method

1 reference

8 April 2019

Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

thiol-dependent deubiquitinase

determination method

1 reference

8 April 2019

TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

determination method

1 reference

8 April 2019

Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

endoplasmic reticulum

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

rough endoplasmic reticulum membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex but Act Independently in Regulation of Interleukin-6 mRNA Degradation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

cytoplasmic ribonucleoprotein granule

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

protein-containing complex

determination method

1 reference

8 April 2019

TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

biological process

positive regulation of p38MAPK cascade

determination method

1 reference

8 April 2019

Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

cellular response to virus

determination method

1 reference

8 April 2019

MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

positive regulation of cell death

determination method

1 reference

8 April 2019

Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

negative regulation of interleukin-6 production

determination method

1 reference

8 April 2019

A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

negative regulation of macrophage activation

determination method

1 reference

8 April 2019

A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

cellular response to tumor necrosis factor

determination method

1 reference

8 April 2019

Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

positive regulation of angiogenesis

determination method

negative regulation of production of miRNAs involved in gene silencing by miRNA

determination method

1 reference

8 April 2019

MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

positive regulation of endothelial cell migration

determination method

1 reference

8 April 2019

Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

protein deubiquitination

determination method

1 reference

8 April 2019

Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

MCP-1 induced protein promotes adipogenesis via oxidative stress, endoplasmic reticulum stress and autophagy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

positive regulation of reactive oxygen species metabolic process

determination method

1 reference

8 April 2019

MCP-1 induced protein promotes adipogenesis via oxidative stress, endoplasmic reticulum stress and autophagy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

protein complex oligomerization

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

regulation of gene expression

determination method

1 reference

8 April 2019

Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

positive regulation of protein import into nucleus

determination method

1 reference

8 April 2019

Antidicer RNAse activity of monocyte chemotactic protein-induced protein-1 is critical for inducing angiogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

negative regulation by host of viral genome replication

determination method

1 reference

8 April 2019

MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

negative regulation of tumor necrosis factor production

determination method

1 reference

8 April 2019

A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

positive regulation of miRNA catabolic process

determination method

negative regulation of NF-kappaB transcription factor activity

determination method

1 reference

8 April 2019

A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

positive regulation of defense response to virus by host

determination method

1 reference

8 April 2019

MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

apoptotic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

negative regulation of I-kappaB kinase/NF-kappaB signaling

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

transcription, DNA-templated

determination method

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5D1E8&geneProductId=UniProtKB:Q5D1E8

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

defense response to virus

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

nervous system development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

regulation of transcription, DNA-templated

determination method

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q5D1E8&geneProductId=UniProtKB:Q5D1E8

determination method

positive regulation of mRNA catabolic process

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

cellular response to lipopolysaccharide

determination method

5 references

8 April 2019

TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

MCPIP1 ribonuclease antagonizes dicer and terminates microRNA biogenesis through precursor microRNA degradation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

A novel CCCH-zinc finger protein family regulates proinflammatory activation of macrophages

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

positive regulation of protein deubiquitination

determination method

1 reference

8 April 2019

TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

cellular response to chemokine

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Monocyte chemotactic protein (MCP)-1 promotes angiogenesis via a novel transcription factor, MCP-1-induced protein (MCPIP)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Monocyte chemoattractant protein-1 induces a novel transcription factor that causes cardiac myocyte apoptosis and ventricular dysfunction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

inflammatory response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

3'-UTR-mediated mRNA destabilization

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

8 April 2019

Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

RNA phosphodiester bond hydrolysis, exonucleolytic

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

immune response-activating signal transduction

determination method

1 reference

8 April 2019

Interleukin-1-inducible MCPIP protein has structural and functional properties of RNase and participates in degradation of IL-1beta mRNA

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q5D1E8

determination method

Ribonuclease Zc3h12a-like, NYN domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q5D1E8

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000362179

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362179

ENSP00000473447

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000473447

ENSP00000492053

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000492053

Google Knowledge Graph ID

0 references

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(1 entry)

dewiki MCPIP1

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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