Forkhead box M1 (Q21108344)

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mammalian protein found in Homo sapiens

FOXM1
forkhead-related protein FKHL16
forkhead box protein M1
transcription factor Trident
hepatocyte nuclear factor 3 forkhead homolog 11
HNF-3/fork-head homolog 11
a novel forkhead box M1 isoform FOXM1D
forkhead box M1-D
MPM-2 reactive phosphoprotein 2
HFH-11
M-phase phosphoprotein 2
winged-helix factor from INS-1 cells
Forkhead, drosophila, homolog-like 16

Language	Label	Description	Also known as
English	Forkhead box M1	mammalian protein found in Homo sapiens	FOXM1 forkhead-related protein FKHL16 forkhead box protein M1 transcription factor Trident hepatocyte nuclear factor 3 forkhead homolog 11 HNF-3/fork-head homolog 11 a novel forkhead box M1 isoform FOXM1D forkhead box M1-D MPM-2 reactive phosphoprotein 2 HFH-11 M-phase phosphoprotein 2 winged-helix factor from INS-1 cells Forkhead, drosophila, homolog-like 16

Statements

1 reference

13 November 2019

UniProt protein ID

winged helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q08050

Winged helix-like DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q08050

Fork head domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fork head domain conserved site1, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fork head domain conserved site 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method or standard

3 references

27 March 2018

Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

27 March 2018

Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

sequence-specific DNA binding

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

DNA-binding transcription factor activity

determination method or standard

4 references

27 March 2018

The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

27 March 2018

Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

27 March 2018

Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

protein binding

determination method or standard

5 references

8 April 2019

FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

8 April 2019

The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

8 April 2019

Regulation of the transcription factor FOXM1c by Cyclin E/CDK2

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

8 April 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

protein kinase binding

determination method or standard

1 reference

8 April 2019

Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method or standard

1 reference

8 April 2019

FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer.

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

DNA-binding transcription repressor activity, RNA polymerase II-specific

determination method or standard

1 reference

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method or standard

4 references

27 March 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

27 March 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

27 March 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method or standard

3 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

DNA-binding transcription factor activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

biological process

positive regulation of double-strand break repair

determination method or standard

1 reference

8 April 2019

Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

regulation of Ras protein signal transduction

determination method or standard

1 reference

8 April 2019

FoxM1, a critical regulator of oxidative stress during oncogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

regulation of reactive oxygen species metabolic process

determination method or standard

1 reference

8 April 2019

FoxM1, a critical regulator of oxidative stress during oncogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

transcription by RNA polymerase II

determination method or standard

1 reference

27 March 2018

Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

regulation of cell cycle

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

cellular response to DNA damage stimulus

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

regulation of cell population proliferation

determination method or standard

1 reference

27 March 2018

The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

regulation of cell growth

determination method or standard

1 reference

27 March 2018

Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

positive regulation of cell population proliferation

determination method or standard

1 reference

8 April 2019

FoxM1, a critical regulator of oxidative stress during oncogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

negative regulation of stress-activated MAPK cascade

determination method or standard

1 reference

8 April 2019

FoxM1, a critical regulator of oxidative stress during oncogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

negative regulation of transcription, DNA-templated

determination method or standard

1 reference

8 April 2019

A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

determination method or standard

1 reference

8 April 2019

Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

anatomical structure morphogenesis

determination method or standard

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

cell differentiation

determination method or standard

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

3 references

27 March 2018

Chk2 mediates stabilization of the FoxM1 transcription factor to stimulate expression of DNA repair genes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

27 March 2018

A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

27 March 2018

Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein: enhancement of transformation and transactivation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q08050&geneProductId=UniProtKB:Q08050

determination method or standard

G2/M transition of mitotic cell cycle

determination method or standard

1 reference

8 April 2019

Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q08050

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

Fork head domain conserved site 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q08050

Fork head domain conserved site1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q08050

Fork head domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q08050

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000342307

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000342307

ENSP00000352901

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000352901

ENSP00000354492

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000354492

ENSP00000442309

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000442309

ENSP00000444541

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000444541

ENSP00000486536

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000486536

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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