Protein tyrosine phosphatase receptor type J (Q21108488)

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mammalian protein found in Homo sapiens
  • human density enhanced phosphatase-1
  • DEP-1
  • susceptibility to colon cancer 1, mouse, homolog of
  • density-enhanced phosphatase 1
  • receptor-type tyrosine-protein phosphatase eta
  • Protein-tyrosine phosphatase receptor type J
  • R-PTP-J
  • CD148 antigen
  • HPTP eta
  • PTPRJ
  • protein tyrosine phosphatase, receptor type, J polypeptide
  • protein-tyrosine phosphatase eta
edit
Language Label Description Also known as
English
Protein tyrosine phosphatase receptor type J
mammalian protein found in Homo sapiens
  • human density enhanced phosphatase-1
  • DEP-1
  • susceptibility to colon cancer 1, mouse, homolog of
  • density-enhanced phosphatase 1
  • receptor-type tyrosine-protein phosphatase eta
  • Protein-tyrosine phosphatase receptor type J
  • R-PTP-J
  • CD148 antigen
  • HPTP eta
  • PTPRJ
  • protein tyrosine phosphatase, receptor type, J polypeptide
  • protein-tyrosine phosphatase eta

Statements

molecular function
phosphatase activity
determination method
IDA
IEA
IMP
6 references
retrieved
9 May 2019
stated in
Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IMP
retrieved
9 May 2019
stated in
An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IEA
retrieved
9 May 2019
stated in
The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
9 May 2019
stated in
Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
9 May 2019
stated in
Primary sequence determinants responsible for site-selective dephosphorylation of the PDGF beta-receptor by the receptor-like protein tyrosine phosphatase DEP-1
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
protein binding
determination method
IPI
10 references
retrieved
9 May 2019
stated in
Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IPI
retrieved
9 May 2019
stated in
Large-scale structural analysis of the classical human protein tyrosine phosphatome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IPI
retrieved
9 May 2019
stated in
Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IPI
retrieved
9 May 2019
stated in
Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IPI
retrieved
9 May 2019
stated in
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IPI
retrieved
9 May 2019
stated in
The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IPI
retrieved
9 May 2019
stated in
Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IPI
retrieved
9 May 2019
stated in
New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IPI
retrieved
9 May 2019
stated in
Association of the protein-tyrosine phosphatase DEP-1 with its substrate FLT3 visualized by in situ proximity ligation assay
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IPI
retrieved
9 May 2019
stated in
Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IPI
protein tyrosine phosphatase activity
determination method
IEA
IDA
IMP
TAS
11 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
TAS
retrieved
8 April 2019
stated in
Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IMP
retrieved
8 April 2019
stated in
Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IEA
retrieved
8 April 2019
stated in
The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
8 April 2019
stated in
CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
8 April 2019
stated in
Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
8 April 2019
stated in
New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
8 April 2019
stated in
Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
8 April 2019
stated in
The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
protein tyrosine phosphatase activity
determination method
IBA
IDA
IEA
IMP
TAS
12 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
TAS
retrieved
9 May 2019
stated in
Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IMP
retrieved
9 May 2019
stated in
Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IEA
retrieved
9 May 2019
stated in
CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
9 May 2019
stated in
Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
9 May 2019
stated in
New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
9 May 2019
stated in
The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
9 May 2019
stated in
The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
9 May 2019
stated in
Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IBA
cell component
biological process
peptidyl-tyrosine dephosphorylation
determination method
IDA
IMP
8 references
retrieved
9 May 2019
stated in
Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IMP
retrieved
9 May 2019
stated in
Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IMP
retrieved
9 May 2019
stated in
CD148 is a membrane protein tyrosine phosphatase present in all hematopoietic lineages and is involved in signal transduction on lymphocytes
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
9 May 2019
stated in
Density-enhanced phosphatase 1 regulates phosphorylation of tight junction proteins and enhances barrier function of epithelial cells
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
9 May 2019
stated in
New role for the protein tyrosine phosphatase DEP-1 in Akt activation and endothelial cell survival
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
9 May 2019
stated in
The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
9 May 2019
stated in
The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA
retrieved
9 May 2019
stated in
Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1
GOA
curator
UniProt
UniProt protein ID
Q12913
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12913
determination method
IDA

Identifiers

 
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