Ring finger protein 135 (Q21108493)

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mammalian protein found in Homo sapiens

REUL
RIG-I E3 ubiquitin ligase
E3 ubiquitin-protein ligase RNF135
RING-type E3 ubiquitin transferase RNF135
RNF135
RING finger protein leading to RIG-I activation
Riplet
RING finger protein 135

Language	Label	Description	Also known as
English	Ring finger protein 135	mammalian protein found in Homo sapiens	REUL RIG-I E3 ubiquitin ligase E3 ubiquitin-protein ligase RNF135 RING-type E3 ubiquitin transferase RNF135 RNF135 RING finger protein leading to RIG-I activation Riplet RING finger protein 135

Statements

1 reference

13 November 2019

UniProt protein ID

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IUD6

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IUD6

Butyrophylin-like, SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

B30.2/SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

SPRY domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SPRY-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, RING-type, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

ribonucleoprotein complex binding

determination method

1 reference

24 April 2018

PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUD6&geneProductId=UniProtKB:Q8IUD6

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUD6

determination method

ubiquitin-protein transferase activity

determination method

4 references

24 April 2018

REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUD6&geneProductId=UniProtKB:Q8IUD6

determination method

24 April 2018

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUD6&geneProductId=UniProtKB:Q8IUD6

determination method

24 April 2018

REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUD6&geneProductId=UniProtKB:Q8IUD6

determination method

24 April 2018

Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUD6&geneProductId=UniProtKB:Q8IUD6

determination method

identical protein binding

determination method

1 reference

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUD6

determination method

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUD6

determination method

ubiquitin-protein transferase activity

determination method

5 references

10 September 2018

REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUD6&geneProductId=UniProtKB:Q8IUD6

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUD6&geneProductId=UniProtKB:Q8IUD6

determination method

10 September 2018

Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUD6&geneProductId=UniProtKB:Q8IUD6

determination method

10 September 2018

REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUD6&geneProductId=UniProtKB:Q8IUD6

determination method

10 September 2018

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUD6&geneProductId=UniProtKB:Q8IUD6

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUD6

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUD6

determination method

8 April 2019

REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUD6

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUD6

determination method

biological process

positive regulation of interferon-beta production

determination method

1 reference

8 April 2019

Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUD6

determination method

negative regulation of type I interferon production

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUD6

determination method

regulation of innate immune response

determination method

1 reference

24 April 2018

Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IUD6&geneProductId=UniProtKB:Q8IUD6

determination method

protein ubiquitination

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUD6

determination method

8 April 2019

Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUD6

determination method

8 April 2019

REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUD6

determination method

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IUD6

determination method

regulation of innate immune response

determination method

Zinc finger, RING-type, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IUD6

SPRY-associated

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IUD6

Zinc finger, RING-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IUD6

Butyrophylin-like, SPRY domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IUD6

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IUD6

B30.2/SPRY domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IUD6

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000323693

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000323693

ENSP00000328340

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000328340

ENSP00000440470

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000440470

ENSP00000411965

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411965

ENSP00000464549

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464549

ENSP00000467799

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000467799

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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