Forkhead box E1 (Q21108586)

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mammalian protein found in Homo sapiens
  • forkhead box protein E2
  • forkhead box protein E1
  • forkhead-related protein FKHL15
  • HFKL5
  • thyroid transcription factor 2
  • HFKH4
  • TTF-2
  • forkhead, drosophila, homolog-like 15
  • HNF-3/fork head-like protein 5
  • FOXE1
edit
Language Label Description Also known as
English
Forkhead box E1
mammalian protein found in Homo sapiens
  • forkhead box protein E2
  • forkhead box protein E1
  • forkhead-related protein FKHL15
  • HFKL5
  • thyroid transcription factor 2
  • HFKH4
  • TTF-2
  • forkhead, drosophila, homolog-like 15
  • HNF-3/fork head-like protein 5
  • FOXE1

Statements

molecular function
sequence-specific DNA binding
determination method
IEA
IMP
IDA
8 references
retrieved
8 April 2019
stated in
A novel missense mutation in human TTF-2 (FKHL15) gene associated with congenital hypothyroidism but not athyreosis
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
MSX1 and TGF-beta3 are novel target genes functionally regulated by FOXE1
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
Maternal isodisomy for chromosome 9 causing homozygosity for a novel FOXE1 mutation in syndromic congenital hypothyroidism
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
Characterization of mutations in the FOXE1 gene in a cohort of unrelated Malaysian patients with congenital hypothyroidism and thyroid dysgenesis
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IEA
retrieved
8 April 2019
stated in
A novel FOXE1 mutation (R73S) in Bamforth-Lazarus syndrome causing increased thyroidal gene expression
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IDA
retrieved
8 April 2019
stated in
Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IDA
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method
IDA
IEA
IMP
ISA
ISM
NAS
10 references
retrieved
27 March 2018
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
NAS
retrieved
27 March 2018
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
ISM
retrieved
27 March 2018
stated in
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
ISA
retrieved
27 March 2018
stated in
Maternal isodisomy for chromosome 9 causing homozygosity for a novel FOXE1 mutation in syndromic congenital hypothyroidism
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
27 March 2018
stated in
A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
27 March 2018
stated in
MSX1 and TGF-beta3 are novel target genes functionally regulated by FOXE1
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
27 March 2018
stated in
A novel missense mutation in human TTF-2 (FKHL15) gene associated with congenital hypothyroidism but not athyreosis
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
27 March 2018
stated in
Characterization of mutations in the FOXE1 gene in a cohort of unrelated Malaysian patients with congenital hypothyroidism and thyroid dysgenesis
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
27 March 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
IEA
retrieved
27 March 2018
stated in
A novel FOXE1 mutation (R73S) in Bamforth-Lazarus syndrome causing increased thyroidal gene expression
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
IDA
DNA-binding transcription factor activity, RNA polymerase II-specific
determination method
IBA
IDA
IEA
IMP
ISA
ISM
NAS
11 references
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
NAS
retrieved
8 April 2019
stated in
A census of human transcription factors: function, expression and evolution
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
ISM
retrieved
8 April 2019
stated in
GOA
curator
Norwegian University of Science and Technology, Systems Biology team
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
ISA
retrieved
8 April 2019
stated in
A novel missense mutation in human TTF-2 (FKHL15) gene associated with congenital hypothyroidism but not athyreosis
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
MSX1 and TGF-beta3 are novel target genes functionally regulated by FOXE1
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
Maternal isodisomy for chromosome 9 causing homozygosity for a novel FOXE1 mutation in syndromic congenital hypothyroidism
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
Characterization of mutations in the FOXE1 gene in a cohort of unrelated Malaysian patients with congenital hypothyroidism and thyroid dysgenesis
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IEA
retrieved
8 April 2019
stated in
A novel FOXE1 mutation (R73S) in Bamforth-Lazarus syndrome causing increased thyroidal gene expression
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IBA
cell component
biological process
regulation of transcription by RNA polymerase II
determination method
IMP
IDA
6 references
retrieved
27 March 2018
stated in
Maternal isodisomy for chromosome 9 causing homozygosity for a novel FOXE1 mutation in syndromic congenital hypothyroidism
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
27 March 2018
stated in
A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
27 March 2018
stated in
MSX1 and TGF-beta3 are novel target genes functionally regulated by FOXE1
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
27 March 2018
stated in
A novel missense mutation in human TTF-2 (FKHL15) gene associated with congenital hypothyroidism but not athyreosis
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
27 March 2018
stated in
Characterization of mutations in the FOXE1 gene in a cohort of unrelated Malaysian patients with congenital hypothyroidism and thyroid dysgenesis
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
27 March 2018
stated in
A novel FOXE1 mutation (R73S) in Bamforth-Lazarus syndrome causing increased thyroidal gene expression
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O00358&geneProductId=UniProtKB:O00358
determination method
IDA
regulation of transcription by RNA polymerase II
determination method
IBA
IDA
IMP
7 references
retrieved
8 April 2019
stated in
A novel missense mutation in human TTF-2 (FKHL15) gene associated with congenital hypothyroidism but not athyreosis
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
MSX1 and TGF-beta3 are novel target genes functionally regulated by FOXE1
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
Maternal isodisomy for chromosome 9 causing homozygosity for a novel FOXE1 mutation in syndromic congenital hypothyroidism
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
Characterization of mutations in the FOXE1 gene in a cohort of unrelated Malaysian patients with congenital hypothyroidism and thyroid dysgenesis
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IMP
retrieved
8 April 2019
stated in
A novel FOXE1 mutation (R73S) in Bamforth-Lazarus syndrome causing increased thyroidal gene expression
GOA
curator
UniProt
UniProt protein ID
O00358
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O00358
determination method
IBA

Identifiers

Freebase ID
/m/03g_sjz
0 references
 
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