NADH:ubiquinone oxidoreductase core subunit S1 (Q21109055)

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mammalian protein found in Homo sapiens

NDUFS1
CI-75kD
Complex I-75kD
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
complex I 75kDa subunit
mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit
complex I, mitochondrial respiratory chain, 75-kD subunit
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)

Language	Label	Description	Also known as
English	NADH:ubiquinone oxidoreductase core subunit S1	mammalian protein found in Homo sapiens	NDUFS1 CI-75kD Complex I-75kD NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial complex I 75kDa subunit mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit complex I, mitochondrial respiratory chain, 75-kD subunit NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)

Statements

1 reference

13 November 2019

UniProt protein ID

NADH:ubiquinone oxidoreductase, subunit G

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28331

2Fe-2S ferredoxin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28331

Molybdopterin oxidoreductase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

2Fe-2S ferredoxin-type iron-sulfur binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

NADH-quinone oxidoreductase, chain G, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Molybdopterin oxidoreductase, 4Fe-4S domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

NADH dehydrogenase activity

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28331&geneProductId=UniProtKB:P28331

determination method

2 iron, 2 sulfur cluster binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

oxidoreductase activity, acting on NAD(P)H

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

4 iron, 4 sulfur cluster binding

determination method

1 reference

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28331&geneProductId=UniProtKB:P28331

determination method

protein binding

determination method

1 reference

8 April 2019

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

NADH dehydrogenase (ubiquinone) activity

determination method

6 references

27 March 2018

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28331&geneProductId=UniProtKB:P28331

determination method

27 March 2018

Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28331&geneProductId=UniProtKB:P28331

determination method

27 March 2018

Leigh syndrome associated with mitochondrial complex I deficiency due to a novel mutation in the NDUFS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28331&geneProductId=UniProtKB:P28331

determination method

27 March 2018

cAMP controls oxygen metabolism in mammalian cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28331&geneProductId=UniProtKB:P28331

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28331&geneProductId=UniProtKB:P28331

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28331&geneProductId=UniProtKB:P28331

determination method

iron-sulfur cluster binding

determination method

NADH dehydrogenase (ubiquinone) activity

determination method

6 references

8 April 2019

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

8 April 2019

Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

8 April 2019

Leigh syndrome associated with mitochondrial complex I deficiency due to a novel mutation in the NDUFS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

8 April 2019

cAMP controls oxygen metabolism in mammalian cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

mitochondrial matrix

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

mitochondrial respiratory chain complex I

determination method

3 references

27 March 2018

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28331&geneProductId=UniProtKB:P28331

determination method

27 March 2018

Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28331&geneProductId=UniProtKB:P28331

determination method

27 March 2018

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28331&geneProductId=UniProtKB:P28331

determination method

determination method

2 references

mitochondrial intermembrane space

determination method

1 reference

8 April 2019

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

determination method

1 reference

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28331&geneProductId=UniProtKB:P28331

determination method

mitochondrial inner membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

plasma membrane respiratory chain complex I

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

mitochondrial respiratory chain complex I

determination method

4 references

8 April 2019

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

8 April 2019

Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

8 April 2019

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

biological process

ATP synthesis coupled electron transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

ATP metabolic process

determination method

1 reference

8 April 2019

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

reactive oxygen species metabolic process

determination method

3 references

8 April 2019

Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

8 April 2019

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

8 April 2019

cAMP controls oxygen metabolism in mammalian cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

mitochondrial respiratory chain complex I assembly

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

regulation of mitochondrial membrane potential

determination method

apoptotic mitochondrial changes

determination method

1 reference

8 April 2019

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

cellular respiration

determination method

2 references

mitochondrial electron transport, NADH to ubiquinone

determination method

1 reference

1 January 2018

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28331&geneProductId=UniProtKB:P28331

determination method

cellular respiration

determination method

3 references

8 April 2019

Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

8 April 2019

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28331

determination method

physically interacts with

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1431

metformin hydrochloride

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1703

Molybdopterin oxidoreductase, 4Fe-4S domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28331

2Fe-2S ferredoxin-type iron-sulfur binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28331

NADH-quinone oxidoreductase, chain G, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28331

NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28331

Molybdopterin oxidoreductase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28331

NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P28331

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000233190

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000233190

ENSP00000392709

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000392709

ENSP00000397760

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000397760

ENSP00000399912

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000399912

ENSP00000409689

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000409689

ENSP00000409766

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000409766

ENSP00000489640

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000489640

ENSP00000489705

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000489705

ENSP00000490583

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000490583

ENSP00000490898

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000490898

ENSP00000490315

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000490315

ENSP00000490092

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000490092

ENSP00000489945

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000489945

ENSP00000395553

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000395553

ENSP00000490454

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000490454

ENSP00000490766

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000490766

ENSP00000389413

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389413

ENSP00000400976

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000400976

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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