Yes1 associated transcriptional regulator (Q21109257)

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mammalian protein found in Homo sapiens
  • yorkie homolog
  • yes-associated protein YAP65 homolog
  • YAP1
  • transcriptional coactivator YAP1
  • 65 kDa Yes-associated protein
  • yes-associated protein 2
  • yes-associated protein 1
  • Yes associated protein 1
  • protein yorkie homolog
  • YAP1 protein, human
edit
Language Label Description Also known as
English
Yes1 associated transcriptional regulator
mammalian protein found in Homo sapiens
  • yorkie homolog
  • yes-associated protein YAP65 homolog
  • YAP1
  • transcriptional coactivator YAP1
  • 65 kDa Yes-associated protein
  • yes-associated protein 2
  • yes-associated protein 1
  • Yes associated protein 1
  • protein yorkie homolog
  • YAP1 protein, human

Statements

molecular function
protein binding
determination method
IPI
42 references
retrieved
9 May 2019
stated in
TEAD mediates YAP-dependent gene induction and growth control
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
PTPN14 interacts with and negatively regulates the oncogenic function of YAP
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Angiomotin-like proteins associate with and negatively regulate YAP1
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
PTPN14 is required for the density-dependent control of YAP1
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Tumor suppressor LATS1 is a negative regulator of oncogene YAP
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Proline-rich Gla protein 2 is a cell-surface vitamin K-dependent protein that binds to the transcriptional coactivator Yes-associated protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Yap1 acts downstream of α-catenin to control epidermal proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Structural and functional analysis of the YAP-binding domain of human TEAD2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
AMPK modulates Hippo pathway activity to regulate energy homeostasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Proteome-wide analysis of phospho-regulated PDZ domain interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Rab11a promotes proliferation and invasion through regulation of YAP in non-small cell lung cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Physical interaction with Yes-associated protein enhances p73 transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Aerobic glycolysis tunes YAP/TAZ transcriptional activity
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
retrieved
9 May 2019
stated in
Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IPI
transcription coactivator activity
determination method
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
Structural insights into the YAP and TEAD complex
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IEA
retrieved
8 April 2019
stated in
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
8 April 2019
stated in
Tumor suppressor LATS1 is a negative regulator of oncogene YAP
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
8 April 2019
stated in
Structural and functional analysis of the YAP-binding domain of human TEAD2
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
8 April 2019
stated in
Aerobic glycolysis tunes YAP/TAZ transcriptional activity
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
transcription coactivator activity
determination method
IBA
IDA
IEA
IMP
7 references
retrieved
9 May 2019
stated in
Structural insights into the YAP and TEAD complex
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IEA
retrieved
9 May 2019
stated in
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
9 May 2019
stated in
Tumor suppressor LATS1 is a negative regulator of oncogene YAP
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
9 May 2019
stated in
Structural and functional analysis of the YAP-binding domain of human TEAD2
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
9 May 2019
stated in
Aerobic glycolysis tunes YAP/TAZ transcriptional activity
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IBA
cell component
nucleus
determination method
IDA
IEA
7 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IEA
retrieved
8 April 2019
stated in
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
8 April 2019
stated in
Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
8 April 2019
stated in
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
8 April 2019
stated in
Tumor suppressor LATS1 is a negative regulator of oncogene YAP
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
8 April 2019
stated in
Aerobic glycolysis tunes YAP/TAZ transcriptional activity
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
8 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IEA
retrieved
9 May 2019
stated in
Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
9 May 2019
stated in
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
9 May 2019
stated in
Tumor suppressor LATS1 is a negative regulator of oncogene YAP
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
9 May 2019
stated in
Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway
GOA
curator
UniProt
UniProt protein ID
P46937
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
9 May 2019
stated in
Aerobic glycolysis tunes YAP/TAZ transcriptional activity
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46937
determination method
IBA
biological process

Identifiers

MeSH descriptor ID
C088374
subject named as
YAP1 protein, human
0 references
PDB structure ID
 
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