Forkhead box O4 (Q21109294)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

forkhead box protein O4
FOXO4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
fork head domain transcription factor AFX1

Language	Label	Description	Also known as
English	Forkhead box O4	mammalian protein found in Homo sapiens	forkhead box protein O4 FOXO4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7 fork head domain transcription factor AFX1

Statements

1 reference

13 November 2019

UniProt protein ID

Winged helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P98177

Winged helix-like DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P98177

FOXO protein, transactivation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fork head domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Fork head domain conserved site 2, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

4 references

8 April 2019

14-3-3 Protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

transcription factor binding

determination method

1 reference

24 April 2018

Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

beta-catenin binding

determination method

1 reference

8 April 2019

Functional interaction between beta-catenin and FOXO in oxidative stress signaling

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

identical protein binding

determination method

1 reference

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

promoter-specific chromatin binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

1 reference

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

sequence-specific DNA binding

determination method

4 references

24 April 2018

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

24 April 2018

DNA-binding specificities of human transcription factors

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

DNA-binding transcription factor activity

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

sequence-specific DNA binding

determination method

5 references

8 April 2019

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

DNA-binding specificities of human transcription factors

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

determination method

3 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

24 April 2018

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

determination method

5 references

8 April 2019

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

determination method

5 references

24 April 2018

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

24 April 2018

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

24 April 2018

Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

determination method

6 references

8 April 2019

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

biological process

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

negative regulation of smooth muscle cell differentiation

determination method

1 reference

8 April 2019

Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

negative regulation of G0 to G1 transition

determination method

1 reference

8 April 2019

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

insulin receptor signaling pathway

determination method

1 reference

24 April 2018

Direct control of the Forkhead transcription factor AFX by protein kinase B

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

negative regulation of angiogenesis

determination method

1 reference

8 April 2019

The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 alpha by a von Hippel-Lindau protein-independent mechanism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

cell differentiation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98177&geneProductId=UniProtKB:P98177

determination method

muscle organ development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

stem cell differentiation

determination method

1 reference

8 April 2019

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

transcription by RNA polymerase II

determination method

1 reference

8 April 2019

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

positive regulation of transcription by RNA polymerase II

determination method

2 references

mitotic G2 DNA damage checkpoint signaling

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

response to water-immersion restraint stress

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

response to nutrient levels

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

positive regulation of smooth muscle cell migration

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

protein deubiquitination

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

glucose homeostasis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

8 April 2019

Functional interaction between beta-catenin and FOXO in oxidative stress signaling

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98177

determination method

Fork head domain conserved site 2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P98177

FOXO protein, transactivation domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P98177

Fork head domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P98177

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000342209

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000342209

ENSP00000363377

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363377

PDB structure ID

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21109294&oldid=2022936688"