Matrix metallopeptidase 14 (Q21109573)

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mammalian protein found in Homo sapiens
  • membrane type 1 metalloprotease
  • matrix metallopeptidase 14 (membrane-inserted)
  • MMP-X1
  • MTMMP1
  • membrane-type-1 matrix metalloproteinase
  • MMP14
  • MT1MMP
  • matrix metalloproteinase-14
  • MT1-MMP
  • Membrane-type matrix metalloproteinase 1
  • MT-MMP 1
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Language Label Description Also known as
English
Matrix metallopeptidase 14
mammalian protein found in Homo sapiens
  • membrane type 1 metalloprotease
  • matrix metallopeptidase 14 (membrane-inserted)
  • MMP-X1
  • MTMMP1
  • membrane-type-1 matrix metalloproteinase
  • MMP14
  • MT1MMP
  • matrix metalloproteinase-14
  • MT1-MMP
  • Membrane-type matrix metalloproteinase 1
  • MT-MMP 1

Statements

part of
molecular function
protein binding
determination method
IPI
13 references
retrieved
8 April 2019
stated in
MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development
GOA
curator
UniProt
UniProt protein ID
P50281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
8 April 2019
stated in
GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase.
GOA
curator
UniProt
UniProt protein ID
P50281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
8 April 2019
stated in
Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors
GOA
curator
UniProt
UniProt protein ID
P50281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
8 April 2019
stated in
BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity
GOA
curator
UniProt
UniProt protein ID
P50281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
8 April 2019
stated in
Furin Functions as a Nonproteolytic Chaperone for Matrix Metalloproteinase-28: MMP-28 Propeptide Sequence Requirement
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
8 April 2019
stated in
Sphingosine-1-phosphate induces the association of membrane-type 1 matrix metalloproteinase with p130Cas in endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
8 April 2019
stated in
Detection of a latent soluble form of membrane type 1 matrix metalloprotease bound with tissue inhibitor of matrix metalloproteinases-2 in periprosthetic tissues and fluids from loose arthroplasty endoprostheses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
8 April 2019
stated in
Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
8 April 2019
stated in
LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
8 April 2019
stated in
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
8 April 2019
stated in
Lumican: a new inhibitor of matrix metalloproteinase-14 activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
8 April 2019
stated in
Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IPI
protein binding
determination method
IBA
IPI
13 references
retrieved
1 January 2018
stated in
Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors
GOA
curator
UniProt
UniProt protein ID
P50281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P50281&geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
1 January 2018
stated in
MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development
GOA
curator
UniProt
UniProt protein ID
P50281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P50281&geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
1 January 2018
stated in
GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase.
GOA
curator
UniProt
UniProt protein ID
P50281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P50281&geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
1 January 2018
stated in
BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity
GOA
curator
UniProt
UniProt protein ID
P50281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P50281&geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
1 January 2018
stated in
FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P50281&geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
1 January 2018
stated in
LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P50281&geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
1 January 2018
stated in
Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P50281&geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
1 January 2018
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P50281&geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
1 January 2018
stated in
Detection of a latent soluble form of membrane type 1 matrix metalloprotease bound with tissue inhibitor of matrix metalloproteinases-2 in periprosthetic tissues and fluids from loose arthroplasty endoprostheses
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P50281&geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
1 January 2018
stated in
Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P50281&geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
1 January 2018
stated in
Sphingosine-1-phosphate induces the association of membrane-type 1 matrix metalloproteinase with p130Cas in endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P50281&geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
1 January 2018
stated in
Lumican: a new inhibitor of matrix metalloproteinase-14 activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P50281&geneProductId=UniProtKB:P50281
determination method
IPI
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P50281&geneProductId=UniProtKB:P50281
determination method
IBA
cell component
biological process
proteolysis
determination method
IDA
IEA
TAS
6 references
retrieved
8 April 2019
stated in
The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
TAS
retrieved
8 April 2019
stated in
A matrix metalloproteinase expressed on the surface of invasive tumour cells
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P50281
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IEA
retrieved
8 April 2019
stated in
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IDA
retrieved
8 April 2019
stated in
Prion fragment peptides are digested with membrane type matrix metalloproteinases and acquire enzyme resistance through Cu²⁺-binding
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P50281
determination method
IDA

Identifiers

 
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