Ubiquitin conjugating enzyme E2 K (Q21109669)

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mammalian protein found in Homo sapiens

ubiquitin conjugating enzyme E2K
E2(25K)
ubiquitin-conjugating enzyme E2-25 KDA
HIP-2
Ubiquitin-conjugating enzyme E2-25K
ubiquitin carrier protein
ubiquitin-protein ligase
huntingtin-interacting protein 2
ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
ubiquitin-conjugating enzyme E2(25K)
UBE2K
ubiquitin-conjugating enzyme E2 K
E2 ubiquitin-conjugating enzyme K

Language	Label	Description	Also known as
English	Ubiquitin conjugating enzyme E2 K	mammalian protein found in Homo sapiens	ubiquitin conjugating enzyme E2K E2(25K) ubiquitin-conjugating enzyme E2-25 KDA HIP-2 Ubiquitin-conjugating enzyme E2-25K ubiquitin carrier protein ubiquitin-protein ligase huntingtin-interacting protein 2 ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast) ubiquitin-conjugating enzyme E2(25K) UBE2K ubiquitin-conjugating enzyme E2 K E2 ubiquitin-conjugating enzyme K

Statements

1 reference

13 November 2019

UniProt protein ID

UBA-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P61086

Ubiquitin-conjugating enzyme/RWD-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P61086

Ubiquitin-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin-conjugating enzyme E2 family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin-conjugating enzyme, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

ubiquitin-ubiquitin ligase activity

determination method

1 reference

8 April 2019

E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

protein binding

determination method

8 references

8 April 2019

E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

8 April 2019

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

8 April 2019

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

8 April 2019

Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

8 April 2019

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

8 April 2019

Development and application of a DNA microarray-based yeast two-hybrid system

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

8 April 2019

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

ubiquitin protein ligase binding

determination method

3 references

8 April 2019

NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

8 April 2019

E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

8 April 2019

The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

ubiquitin conjugating enzyme activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

biological process

protein K48-linked ubiquitination

determination method

1 reference

8 April 2019

The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

positive regulation of type I interferon-mediated signaling pathway

determination method

1 reference

8 April 2019

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

free ubiquitin chain polymerization

determination method

1 reference

8 April 2019

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

positive regulation of peptidyl-threonine phosphorylation

determination method

1 reference

8 April 2019

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

ubiquitin-dependent protein catabolic process

determination method

1 reference

8 April 2019

Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

cellular response to interferon-beta

determination method

1 reference

8 April 2019

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

proteasome-mediated ubiquitin-dependent protein catabolic process

determination method

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P61086&geneProductId=UniProtKB:P61086

determination method

regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P61086

determination method

Ubiquitin-conjugating enzyme, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P61086

Ubiquitin-associated domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P61086

Ubiquitin-conjugating enzyme E2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P61086

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000261427

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000261427

ENSP00000390483

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000390483

ENSP00000421203

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421203

ENSP00000421422

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000421422

ENSP00000425301

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425301

PDB structure ID

1 reference

UniProt protein ID

19 March 2016

language of work or name

1 reference

UniProt protein ID

19 March 2016

language of work or name

1 reference

UniProt protein ID

19 March 2016

language of work or name

1 reference

UniProt protein ID

19 March 2016

language of work or name

1 reference

UniProt protein ID

19 March 2016

language of work or name

1 reference

UniProt protein ID

19 March 2016

language of work or name

1 reference

UniProt protein ID

19 March 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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