2'-5'-oligoadenylate synthetase 2 (Q21109795)

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mammalian protein found in Homo sapiens

OAS2
p69 OAS / p71 OAS
p69OAS / p71OAS
2'-5'-oligoadenylate synthase 2
(2'-5')oligo(A) synthetase 2
2-5A synthase 2
2'-5'-oligoadenylate synthetase 2, 69/71kDa

Language	Label	Description	Also known as
English	2'-5'-oligoadenylate synthetase 2	mammalian protein found in Homo sapiens	OAS2 p69 OAS / p71 OAS p69OAS / p71OAS 2'-5'-oligoadenylate synthase 2 (2'-5')oligo(A) synthetase 2 2-5A synthase 2 2'-5'-oligoadenylate synthetase 2, 69/71kDa

Statements

1 reference

13 November 2019

UniProt protein ID

2'-5'-oligoadenylate synthase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P29728

2'-5'-oligoadenylate synthetase 1, domain 2/C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Polymerase, nucleotidyl transferase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

2-5-oligoadenylate synthetase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

2-5-oligoadenylate synthetase, C-terminal conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

zinc ion binding

determination method

1 reference

26 September 2017

Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

2'-5'-oligoadenylate synthetase activity

determination method

5 references

26 September 2017

The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

26 September 2017

Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

26 September 2017

Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

protein binding

determination method

1 reference

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

determination method

2 references

double-stranded RNA binding

determination method

4 references

26 September 2017

The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

26 September 2017

Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

determination method

2'-5'-oligoadenylate synthetase activity

determination method

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

1 January 2018

The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

1 January 2018

Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

double-stranded RNA binding

determination method

5 references

8 April 2019

The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

8 April 2019

Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

2'-5'-oligoadenylate synthetase activity

determination method

5 references

8 April 2019

The nature of the catalytic domain of 2'-5'-oligoadenylate synthetases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

8 April 2019

Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

endoplasmic reticulum

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

determination method

1 reference

26 September 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

determination method

2 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

26 September 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

intracellular membrane-bounded organelle

determination method

3 references

26 September 2017

Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

26 September 2017

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

determination method

biological process

purine nucleotide biosynthetic process

determination method

1 reference

26 September 2017

Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

interferon-gamma-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

protein myristoylation

determination method

1 reference

26 September 2017

Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

response to virus

determination method

1 reference

8 April 2019

The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

RNA catabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

protein glycosylation

determination method

1 reference

26 September 2017

Enzymatic characteristics of recombinant medium isozyme of 2'-5' oligoadenylate synthetase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

type I interferon signaling pathway

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P29728&geneProductId=UniProtKB:P29728

determination method

immune response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

innate immune response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

nucleobase-containing compound metabolic process

determination method

1 reference

8 April 2019

Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

response to bacterium

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

defense response to virus

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

type I interferon signaling pathway

determination method

regulation of ribonuclease activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P29728

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000342278

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000342278

ENSP00000376362

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000376362

ENSP00000411763

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411763

ENSP00000446977

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446977

ENSP00000450307

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450307

ENSP00000483679

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000483679

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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