ERCC excision repair 1, endonuclease non-catalytic subunit (Q21110095)

protein domain specific binding

English

molecular function

1 reference

8 April 2019

Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

single-stranded DNA binding

IPI

single-stranded DNA endodeoxyribonuclease activity

1 reference

16 July 2018

Purification and characterization of the XPF-ERCC1 complex of human DNA repair excision nuclease

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07992&geneProductId=UniProtKB:P07992

protein C-terminus binding

1 reference

8 April 2019

Mapping of interaction domains between human repair proteins ERCC1 and XPF

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

17 references

8 April 2019

Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Reconstitution of human excision nuclease with recombinant XPF-ERCC1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

XPA versus ERCC1 as chemosensitising agents to cisplatin and mitomycin C in prostate cancer cells: role of ERCC1 in homologous recombination repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Purification and characterization of the XPF-ERCC1 complex of human DNA repair excision nuclease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Functional and physical interactions between ERCC1 and MSH2 complexes for resistance to cis-diamminedichloroplatinum(II) in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

TFIID-class transcription factor complex binding

IPI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

3' overhang single-stranded DNA endodeoxyribonuclease activity

1 reference

8 April 2019

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

single-stranded DNA binding

3 references

8 April 2019

Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:K7EK97

2 references

transcription factor TFIID complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

nucleotide-excision repair factor 1 complex

1 reference

16 July 2018

Domain mapping of the DNA binding, endonuclease, and ERCC1 binding properties of the human DNA repair protein XPF

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07992&geneProductId=UniProtKB:P07992

nucleotide-excision repair complex

3 references

8 April 2019

Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Purification and characterization of the XPF-ERCC1 complex of human DNA repair excision nuclease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Evolution and mutagenesis of the mammalian excision repair gene ERCC-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:K7EK97

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

nucleotide-excision repair factor 1 complex

3 references

8 April 2019

XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

biological process

germ cell development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

male gonad development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

multicellular organism growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

embryonic organ development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

post-embryonic hemopoiesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

response to oxidative stress

chromosome organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

pyrimidine dimer repair by nucleotide-excision repair

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

global genome nucleotide-excision repair

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

multicellular organism aging

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

negative regulation of telomere maintenance

1 reference

8 April 2019

XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

transcription-coupled nucleotide-excision repair

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

Mutational analysis of the human nucleotide excision repair gene ERCC1

TAS

mitotic recombination

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07992&geneProductId=UniProtKB:P07992

cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

nucleotide-excision repair, DNA incision

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

nucleotide-excision repair

3 references

8 April 2019

The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Evolution and mutagenesis of the mammalian excision repair gene ERCC-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

nucleotide-excision repair, preincision complex stabilization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

double-strand break repair

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

4 references

8 April 2019

USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

meiotic mismatch repair

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

double-strand break repair via nonhomologous end joining

1 reference

8 April 2019

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

UV-damage excision repair

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

negative regulation of protection from non-homologous end joining at telomere

1 reference

8 April 2019

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

telomeric DNA-containing double minutes formation

1 reference

8 April 2019

ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

response to immobilization stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

response to cadmium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

nucleotide-excision repair, DNA incision, 3'-to lesion

1 reference

1 January 2018

Human DNA repair excision nuclease. Analysis of the roles of the subunits involved in dual incisions by using anti-XPG and anti-ERCC1 antibodies

http://www.ebi.ac.uk/QuickGO/annotations?protein=P07992&geneProductId=UniProtKB:P07992

nucleotide-excision repair, DNA incision, 5'-to lesion

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Human DNA repair excision nuclease. Analysis of the roles of the subunits involved in dual incisions by using anti-XPG and anti-ERCC1 antibodies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P07992

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:K7EK97

nucleic acid phosphodiester bond hydrolysis

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:K7EK97

Commons category

DNA excision repair protein ERCC-1

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Identifiers

MeSH descriptor ID

C071447

subject named as

ERCC1 protein, human

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13 November 2019

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20 March 2016

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9 August 2016