CDK5 regulatory subunit associated protein 3 (Q21110691)

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mammalian protein found in Homo sapiens

CDK5RAP3
CDK5 regulatory subunit-associated protein 3
CDK5 regulatory subunit associated protein IC53-2
ischemic heart CDK5 activator-binding protein C53
LXXLL/leucine-zipper-containing ARF-binding protein
Protein HSF-27
CDK5 activator-binding protein C53
LXXLL/leucine-zipper-containing ARFbinding protein

Language	Label	Description	Also known as
English	CDK5 regulatory subunit associated protein 3	mammalian protein found in Homo sapiens	CDK5RAP3 CDK5 regulatory subunit-associated protein 3 CDK5 regulatory subunit associated protein IC53-2 ischemic heart CDK5 activator-binding protein C53 LXXLL/leucine-zipper-containing ARF-binding protein Protein HSF-27 CDK5 activator-binding protein C53 LXXLL/leucine-zipper-containing ARFbinding protein

Statements

1 reference

13 November 2019

UniProt protein ID

CDK5 regulatory subunit-associated protein 3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96JB5

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

MDM2/MDM4 family protein binding

determination method

1 reference

8 April 2019

A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

NF-kappaB binding

determination method

1 reference

8 April 2019

LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

mitogen-activated protein kinase binding

determination method

1 reference

8 April 2019

LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

protein binding

determination method

6 references

8 April 2019

A novel LZAP-binding protein, NLBP, inhibits cell invasion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

8 April 2019

A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

8 April 2019

A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

8 April 2019

LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

determination method

1 reference

8 April 2019

Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

8 April 2019

Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

8 April 2019

A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

8 April 2019

Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

8 April 2019

Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

determination method

1 reference

8 April 2019

Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

determination method

1 reference

26 September 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96JB5&geneProductId=UniProtKB:Q96JB5

determination method

microtubule organizing center

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

determination method

1 reference

8 April 2019

Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

endomembrane system

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96JB5&geneProductId=UniProtKB:Q96JB5

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

determination method

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

protein-containing complex

determination method

1 reference

8 April 2019

Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

biological process

negative regulation of protein phosphorylation

determination method

1 reference

8 April 2019

LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

regulation of neuron differentiation

determination method

1 reference

8 April 2019

Cloning of three novel neuronal Cdk5 activator binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

protein ufmylation

determination method

1 reference

8 April 2019

Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

positive regulation of signal transduction by p53 class mediator

determination method

1 reference

8 April 2019

A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

regulation of phosphatase activity

determination method

1 reference

8 April 2019

LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

endoplasmic reticulum unfolded protein response

determination method

1 reference

8 April 2019

Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

mitotic G2/M transition checkpoint

determination method

1 reference

8 April 2019

Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

brain development

determination method

1 reference

8 April 2019

Identification of a common protein association region in the neuronal Cdk5 activator

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

apoptotic nuclear changes

determination method

1 reference

8 April 2019

Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

negative regulation of MAP kinase activity

determination method

1 reference

8 April 2019

LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

positive regulation of ubiquitin-dependent protein catabolic process

determination method

1 reference

8 April 2019

A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

negative regulation of protein kinase activity by regulation of protein phosphorylation

determination method

1 reference

8 April 2019

LZAP inhibits p38 MAPK (p38) phosphorylation and activity by facilitating p38 association with the wild-type p53 induced phosphatase 1 (WIP1)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

negative regulation of protein serine/threonine kinase activity

determination method

1 reference

8 April 2019

Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

cell population proliferation

determination method

1 reference

8 April 2019

A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

mitotic G2 DNA damage checkpoint signaling

determination method

1 reference

8 April 2019

Cdk5 activator-binding protein C53 regulates apoptosis induced by genotoxic stress via modulating the G2/M DNA damage checkpoint

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

negative regulation of NF-kappaB transcription factor activity

determination method

positive regulation of protein ubiquitination

determination method

1 reference

8 April 2019

A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

positive regulation of protein localization to nucleus

determination method

1 reference

8 April 2019

A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

regulation of mitotic cell cycle

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96JB5

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000344683

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000344683

ENSP00000438886

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000438886

ENSP00000462012

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462012

ENSP00000462042

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462042

ENSP00000462328

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462328

ENSP00000462431

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462431

ENSP00000462886

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462886

ENSP00000463431

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463431

ENSP00000463442

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463442

ENSP00000463878

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463878

ENSP00000463950

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463950

ENSP00000464286

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464286

ENSP00000464419

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464419

ENSP00000464542

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464542

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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