CDK5 regulatory subunit associated protein 2 (Q21110695)

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mammalian protein found in Homo sapiens

centrosomin
Centrosome-associated protein 215
CDK5 activator-binding protein C48
CDK5 regulatory subunit-associated protein 2
centrosomal protein 215 kDa
CDK5RAP2

Language	Label	Description	Also known as
English	CDK5 regulatory subunit associated protein 2	mammalian protein found in Homo sapiens	centrosomin Centrosome-associated protein 215 CDK5 activator-binding protein C48 CDK5 regulatory subunit-associated protein 2 centrosomal protein 215 kDa CDK5RAP2

Statements

1 reference

13 November 2019

UniProt protein ID

Centrosomin, N-terminal motif 1, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

microtubule binding

determination method

1 reference

8 April 2019

Proteomic characterization of the human centrosome by protein correlation profiling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

tubulin binding

determination method

1 reference

8 April 2019

CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

protein binding

determination method

9 references

8 April 2019

Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

CDK5RAP2 is required for spindle checkpoint function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

protein kinase binding

determination method

1 reference

8 April 2019

Cloning of three novel neuronal Cdk5 activator binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

gamma-tubulin binding

determination method

1 reference

8 April 2019

EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

CDK5RAP2 is required for spindle checkpoint function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

mitotic spindle pole

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

determination method

13 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

Proteomic characterization of the human centrosome by protein correlation profiling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

CDK5RAP2 is required for spindle checkpoint function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

pericentriolar material

determination method

1 reference

8 April 2019

CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

microtubule plus-end

determination method

1 reference

8 April 2019

Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

perinuclear region of cytoplasm

determination method

1 reference

8 April 2019

CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

extracellular exosome

determination method

1 reference

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

biological process

regulation of neuron differentiation

determination method

1 reference

8 April 2019

Cloning of three novel neuronal Cdk5 activator binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

negative regulation of neuron differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

chromosome segregation

determination method

1 reference

8 April 2019

CDK5RAP2 is required for spindle checkpoint function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

CDK5RAP2 is required for spindle checkpoint function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

brain development

determination method

3 references

8 April 2019

Identification of a common protein association region in the neuronal Cdk5 activator

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

G2/M transition of mitotic cell cycle

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

microtubule bundle formation

determination method

1 reference

8 April 2019

Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

regulation of spindle checkpoint

determination method

1 reference

17 October 2017

CDK5RAP2 is required for spindle checkpoint function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96SN8&geneProductId=UniProtKB:Q96SN8

determination method

centriole replication

determination method

1 reference

8 April 2019

Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

microtubule organizing center organization

determination method

1 reference

8 April 2019

Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

microtubule cytoskeleton organization

determination method

1 reference

8 April 2019

CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

ciliary basal body-plasma membrane docking

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

centrosome cycle

determination method

1 reference

8 April 2019

Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

regulation of G2/M transition of mitotic cell cycle

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

positive regulation of microtubule polymerization

determination method

1 reference

8 April 2019

EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

regulation of mitotic cell cycle spindle assembly checkpoint

determination method

1 reference

8 April 2019

CDK5RAP2 is required for spindle checkpoint function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96SN8

determination method

physically interacts with

determination method

Affinity Capture-MS

1 reference

https://thebiogrid.org/news/227

19 April 2020

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing

Centrosomin, N-terminal motif 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96SN8

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000343818

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000343818

ENSP00000353317

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353317

ENSP00000354065

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000354065

ENSP00000400395

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000400395

ENSP00000409941

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000409941

ENSP00000417925

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417925

ENSP00000418418

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418418

ENSP00000419265

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419265

ENSP00000419640

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000419640

Sitelinks

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