cytochrome P450 family 21 subfamily A member 2 (Q21110736)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

• Cytochrome P450-C21
• 21-OHase
• steroid 21-monooxygenase
• CYP21A2
• Cytochrome P-450c21
• steroid 21 hydroxylase
• steroid 21-hydroxylase
• cytochrome P450 XXI
• cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2
• Cytochrome P450 21
• cytochrome P450, family 21, subfamily A, polypeptide 2
• cytochrome P450-C21B
• 21-hydroxylase

edit

Language	Label	Description	Also known as
English	cytochrome P450 family 21 subfamily A member 2	mammalian protein found in Homo sapiens	Cytochrome P450-C21 21-OHase steroid 21-monooxygenase CYP21A2 Cytochrome P-450c21 steroid 21 hydroxylase steroid 21-hydroxylase cytochrome P450 XXI cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2 Cytochrome P450 21 cytochrome P450, family 21, subfamily A, polypeptide 2 cytochrome P450-C21B 21-hydroxylase

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P08686

part of

cytochrome P450 superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P08686

cytochrome P450, E-class, group I

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P08686

cytochrome P450, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

Full Structure of 21-Hydroxylase.png
1,280 × 1,072; 624 KB

media legend

Crystallographic structure of 21-hydroxylase. Rainbow colored cartoon (N-terminus blue, C-terminus red. (English)

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P08686

encoded by

CYP21A2

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P08686

molecular function

iron ion binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IEA

metal ion binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IEA

monooxygenase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IEA

steroid hydroxylase activity

determination method

TAS

IMP

2 references

retrieved

8 April 2019

stated in

R339H and P453S: CYP21 mutations associated with nonclassic steroid 21-hydroxylase deficiency that are not apparent gene conversions

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

TAS

retrieved

8 April 2019

stated in

Four novel missense mutations in the CYP21A2 gene detected in Russian patients suffering from the classical form of congenital adrenal hyperplasia: identification, functional characterization, and structural analysis

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IMP

steroid binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IEA

heme binding

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IEA

retrieved

8 April 2019

stated in

Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IDA

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IEA

oxidoreductase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IEA

lipid binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IEA

steroid 21-monooxygenase activity

determination method

IDA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

TAS

retrieved

8 April 2019

stated in

Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IDA

cell component

organelle membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IEA

endoplasmic reticulum membrane

determination method

IEA

TAS

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IEA

membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IEA

intracellular membrane-bounded organelle

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IEA

endoplasmic reticulum

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IEA

biological process

glucocorticoid biosynthetic process

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

TAS

mineralocorticoid biosynthetic process

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

TAS

sterol metabolic process

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

TAS

steroid biosynthetic process

determination method

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IEA

retrieved

8 April 2019

stated in

Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IDA

steroid metabolic process

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Four novel missense mutations in the CYP21A2 gene detected in Russian patients suffering from the classical form of congenital adrenal hyperplasia: identification, functional characterization, and structural analysis

GOA

curator

UniProt

UniProt protein ID

P08686

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P08686

determination method

IMP

EC enzyme number

1.14.14.16

0 references

has part(s)

cytochrome P450, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P08686

Identifiers

CAS Registry Number

9029-68-9

0 references

MeSH descriptor ID

D013255

subject named as

Steroid 21-Hydroxylase

0 references

MeSH tree code

D08.244.453.493.500

0 references

D08.244.453.915.760

0 references

D08.811.682.690.708.170.463.500

0 references

D08.811.682.690.708.170.915.760

0 references

D12.776.422.220.453.493.500

0 references

D12.776.422.220.453.915.760

0 references

RefSeq protein ID

NP_000491

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1589

NP_001122062

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1589

XP_024308323

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1589

NP_001355072

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1589

NP_001355073

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1589

UniProt protein ID

P08686

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P08686

Ensembl protein ID

ENSP00000372811

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000372811

ENSP00000392321

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000392321

ENSP00000398594

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000398594

ENSP00000403230

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000403230

ENSP00000403721

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000403721

ENSP00000415043

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000415043

ENSP00000418561

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000418561

ENSP00000394942

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000394942

ENSP00000417321

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000417321

ENSP00000390312

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000390312

ENSP00000372812

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000372812

ENSP00000418104

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000418104

ENSP00000407338

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000407338

ENSP00000419572

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000419572

ENSP00000416598

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000416598

ENSP00000496625

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000496625

Freebase ID

/m/027m1q0

0 references

Microsoft Academic ID

2780321258

0 references

OpenAlex ID

C2780321258

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

4Y8W

1 reference

stated in

UniProt

UniProt protein ID

P08686

retrieved

4 August 2016

language of work or name

English

UMLS CUI

C0038304

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

stated in

UMLS 2023

retrieved

24 May 2023

 

Sitelinks

Wikipedia(15 entries)

edit

• arwiki هيدروكسيلاز-21
• bswiki CYP21A2
• dewiki Steroid-21-Hydroxylase
• enwiki 21-Hydroxylase
• fawiki ۲۱-هیدروکسیلاز
• frwiki 21-Hydroxylase
• itwiki Steroide 21-monoossigenasi
• jawiki ステロイド-21-モノオキシゲナーゼ
• lawiki 21-hydroxylasis
• plwiki 21-Hydroksylaza
• ptwiki 21-hidroxilase
• ruwiki 21-гидроксилаза
• shwiki Steroid 21-monooksigenaza
• srwiki Steroid 21-monooksigenaza
• ukwiki CYP21A2

Wikibooks(0 entries)

edit

Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21110736&oldid=2022942847"