Dopamine receptor D3 (Q21110872)

http://www.ebi.ac.uk/interpro/protein/P35462

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.3.9

hierarchical database ID heuristic

2 October 2019

based on heuristic

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

image

3PBL (D3).png
775 × 925; 351 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

4 references

8 April 2019

Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

G protein-coupled receptors directly bind filamin A with high affinity and promote filamin phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Modulation of dopamine D(2) receptor signaling by actin-binding protein (ABP-280)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

signal transducer activity

IPI

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

dopamine neurotransmitter receptor activity, coupled via Gi/Go

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

16 July 2018

Expression and pharmacological characterization of the human D3 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

protein domain specific binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

D1 dopamine receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

dopamine neurotransmitter receptor activity, coupled via Gi/Go

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Expression and pharmacological characterization of the human D3 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

adrenergic receptor activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

DISC1 regulates primary cilia that display specific dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

integral component of plasma membrane

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

16 July 2018

Dopamine D4 receptors elevated in schizophrenia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

16 July 2018

Expression and pharmacological characterization of the human D3 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

glutamatergic synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

integral component of postsynaptic density membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

integral component of plasma membrane

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Dopamine D4 receptors elevated in schizophrenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Expression and pharmacological characterization of the human D3 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

negative regulation of sodium:proton antiporter activity

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

dopamine receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

dopamine metabolic process

1 reference

8 April 2019

Expression and pharmacological characterization of the human D3 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

regulation of circadian sleep/wake cycle, sleep

IC

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

negative regulation of dopamine receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

positive regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

regulation of dopamine uptake involved in synaptic transmission

1 reference

8 April 2019

Expression and pharmacological characterization of the human D3 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors

IC

response to histamine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

1 reference

8 April 2019

The dopamine D(3) receptor Ser9Gly polymorphism modulates prepulse inhibition of the acoustic startle reflex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

1 reference

8 April 2019

Polymorphisms of DRD4 and DRD3 and risk of avoidant and obsessive personality traits and disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

1 reference

8 April 2019

Habit learning and the genetics of the dopamine D3 receptor: evidence from patients with schizophrenia and healthy controls

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

positive regulation of renal sodium excretion

NAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

arachidonic acid secretion

1 reference

8 April 2019

Expression and pharmacological characterization of the human D3 dopamine receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

negative regulation of protein secretion

1 reference

8 April 2019

Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

regulation of blood volume by renin-angiotensin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

regulation of locomotion involved in locomotory behavior

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

cellular calcium ion homeostasis

1 reference

8 April 2019

Functional expression of human D3 dopamine receptors in differentiated neuroblastoma x glioma NG108-15 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

regulation of locomotion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

1 reference

8 April 2019

Role of dopamine D3 receptor (DRD3) and dopamine transporter (DAT) polymorphism in cognitive dysfunctions and therapeutic response to atypical antipsychotics in patients with schizophrenia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

NAS

response to amphetamine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

positive regulation of transcription by RNA polymerase II

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

positive regulation of cytokinesis

1 reference

8 April 2019

G protein-coupled receptors participate in cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

regulation of lipid metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

regulation of multicellular organism growth

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

behavioral response to cocaine

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

16 July 2018

Adaptive increase in D3 dopamine receptors in the brain reward circuits of human cocaine fatalities

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

adenylate cyclase-inhibiting dopamine receptor signaling pathway

5 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

16 July 2018

Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

16 July 2018

Chimeric D2/D3 dopamine receptors efficiently inhibit adenylyl cyclase in HEK 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

16 July 2018

Functional expression and characterization of human D2 and D3 dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

synaptic transmission, dopaminergic

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35462&geneProductId=UniProtKB:P35462

G protein-coupled receptor signaling pathway

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Functional expression of human D3 dopamine receptors in differentiated neuroblastoma x glioma NG108-15 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

negative regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

regulation of neurotransmitter uptake

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

regulation of postsynaptic neurotransmitter receptor internalization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

adenylate cyclase-inhibiting dopamine receptor signaling pathway

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Functional expression and characterization of human D2 and D3 dopamine receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Chimeric D2/D3 dopamine receptors efficiently inhibit adenylyl cyclase in HEK 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

regulation of dopamine secretion

behavioral response to cocaine

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Adaptive increase in D3 dopamine receptors in the brain reward circuits of human cocaine fatalities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

adenylate cyclase-activating adrenergic receptor signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P35462

physically interacts with

1 reference

7683

17 August 2016

1 reference

7295

17 August 2016

1 reference

941

17 August 2016

1 reference

7427

English

7-hydroxy-2-(di-N-propylamino)tetralin

17 August 2016

has use

agonist

1 reference

950

17 August 2016

1 reference

940

17 August 2016

1 reference

953

17 August 2016

1 reference

954

17 August 2016

1 reference

2

17 August 2016

1 reference

33

17 August 2016

1 reference

7625

17 August 2016

1 reference

35

17 August 2016

1 reference

37

17 August 2016

1 reference

43

17 August 2016

1 reference

48

17 August 2016

1 reference

49

17 August 2016

1 reference

52

17 August 2016

1 reference

56

17 August 2016

1 reference

62

17 August 2016

1 reference

83

17 August 2016

1 reference

38

17 August 2016

1 reference

965

17 August 2016

1 reference

966

17 August 2016

1 reference

948

17 August 2016

1 reference

86

17 August 2016

1 reference

205

17 August 2016

1 reference

7227

17 August 2016

1 reference

44

English

5-chloro-2-methoxy-4-(methylamino)-N-(2-methyl-1-(phenylmethyl)-3-pyrrolidinyl)benzamide

17 August 2016

has use

1 reference

983

17 August 2016

1 reference

7556

17 August 2016

1 reference

90

17 August 2016

1 reference

7279

17 August 2016

1 reference

7281

17 August 2016

1 reference

94

17 August 2016

1 reference

96

17 August 2016

1 reference

143

17 August 2016

1 reference

98

17 August 2016

1 reference

99

17 August 2016

1 reference

5501

17 August 2016

1 reference

958

17 August 2016

1 reference

103

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1423

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1108

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL54

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL53

thioridazine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200916

bromocriptine mesylate

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200503

chlorpromazine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1713

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1275

promazine hydrochloride

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200469

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35462

Commons category

DRD3

0 references

Identifiers

MeSH descriptor ID

D050637

subject named as

Receptors, Dopamine D3

0 references

MeSH tree code

D12.776.543.750.670.300.400.500.249

0 references

D12.776.543.750.695.150.400.500.500

0 references

D12.776.543.750.720.330.400.500.249

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

9 August 2016

Transporter Classification Database ID

English

9.A.14.3.9

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023