ALK receptor tyrosine kinase (Q21111336)

Protein kinase-like domain superfamily

1 reference

LDL receptor-like superfamily

1 reference

ALK tyrosine kinase receptor

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

MAM domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A repeat, protein family

1 reference

Tyrosine-protein kinase, receptor class II, conserved site, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

protein kinase activity

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

NF-kappaB-inducing kinase activity

1 reference

8 April 2019

Anaplastic lymphoma kinase: signalling in development and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

3 references

8 April 2019

FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

identical protein binding

IPI

1 reference

8 April 2019

ALK mutations confer differential oncogenic activation and sensitivity to ALK inhibition therapy in neuroblastoma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

2 references

transmembrane receptor protein tyrosine kinase activity

4 references

26 September 2017

Anaplastic lymphoma kinase: signalling in development and disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM73&geneProductId=UniProtKB:Q9UM73

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM73&geneProductId=UniProtKB:Q9UM73

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM73&geneProductId=UniProtKB:Q9UM73

26 September 2017

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM73&geneProductId=UniProtKB:Q9UM73

protein tyrosine kinase activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

transmembrane receptor protein tyrosine kinase activity

5 references

8 April 2019

Anaplastic lymphoma kinase: signalling in development and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

integral component of membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

2 references

extracellular exosome

1 reference

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM73&geneProductId=UniProtKB:Q9UM73

integral component of plasma membrane

3 references

26 September 2017

Anaplastic lymphoma kinase: signalling in development and disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM73&geneProductId=UniProtKB:Q9UM73

26 September 2017

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM73&geneProductId=UniProtKB:Q9UM73

26 September 2017

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM73&geneProductId=UniProtKB:Q9UM73

intracellular anatomical structure

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM73&geneProductId=UniProtKB:Q9UM73

integral component of plasma membrane

4 references

8 April 2019

Anaplastic lymphoma kinase: signalling in development and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

protein-containing complex

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

Large-scale proteomics and phosphoproteomics of urinary exosomes

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

regulation of apoptotic process

HDA

biological process

1 reference

8 April 2019

Anaplastic lymphoma kinase: signalling in development and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

transmembrane receptor protein tyrosine kinase signaling pathway

TAS

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM73&geneProductId=UniProtKB:Q9UM73

nervous system development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

protein phosphorylation

1 reference

8 April 2019

positive regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

Anaplastic lymphoma kinase: signalling in development and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

cell population proliferation

TAS

1 reference

8 April 2019

Anaplastic lymphoma kinase: signalling in development and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

protein autophosphorylation

TAS

3 references

8 April 2019

Anaplastic lymphoma kinase: signalling in development and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

peptidyl-tyrosine phosphorylation

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

NIK/NF-kappaB signaling

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

4 references

8 April 2019

Anaplastic lymphoma kinase: signalling in development and disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

8 April 2019

ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

hippocampus development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

regulation of cell population proliferation

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UM73&geneProductId=UniProtKB:Q9UM73

regulation of dopamine receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

response to environmental enrichment

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

regulation of neuron differentiation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UM73

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7741

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

7397

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

4903

17 August 2016

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2403108

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1738797

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1983268

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3545360

alectinib hydrochloride

object has role

reaction inhibitor

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3707320

has part(s)

tyrosine-protein kinase, active site

1 reference

MAM domain

1 reference

protein kinase domain

1 reference

protein kinase, ATP binding site

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

low-density lipoprotein (LDL) receptor class A repeat

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

tyrosine-protein kinase, receptor class II, conserved site

1 reference

Identifiers

MeSH descriptor ID

C000626173

subject named as

ALK protein, human

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30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

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4 August 2016

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4 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023