RAB5A, member RAS oncogene family (Q21111353)

http://www.ebi.ac.uk/interpro/protein/P20339

P-loop containing nucleoside triphosphate hydrolase

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20339

Small GTP-binding protein domain family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

24 references

8 April 2019

Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Rab18 and a Rab18 GEF complex are required for normal ER structure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Structural basis of Rab5-Rabaptin5 interaction in endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

RabGEFs are a major determinant for specific Rab membrane targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Structural basis of family-wide Rab GTPase recognition by rabenosyn-5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

A role of OCRL in clathrin-coated pit dynamics and uncoating revealed by studies of Lowe syndrome cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Direct interaction of EEA1 with Rab5b

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

6 references

9 May 2017

The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

9 May 2017

Structural basis of Rab5-Rabaptin5 interaction in endocytosis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

9 May 2017

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

9 May 2017

Rab18 and a Rab18 GEF complex are required for normal ER structure

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

guanyl nucleotide binding

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

7 references

8 April 2019

The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Rab18 and a Rab18 GEF complex are required for normal ER structure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Structural basis of Rab5-Rabaptin5 interaction in endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Membrane targeting by APPL1 and APPL2: dynamic scaffolds that oligomerize and bind phosphoinositides

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

3 references

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

1 reference

8 April 2019

Real-time imaging of Rab3a and Rab5a reveals differential roles in presynaptic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

somatodendritic compartment

ISS

1 reference

8 April 2019

Real-time imaging of Rab3a and Rab5a reveals differential roles in presynaptic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 references

9 May 2017

Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

9 May 2017

Structural basis of Rab5-Rabaptin5 interaction in endocytosis

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

9 May 2017

Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

9 May 2017

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

9 May 2017

Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

9 May 2017

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

9 May 2017

The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

cytoplasmic side of early endosome membrane

1 reference

8 April 2019

RabGEFs are a major determinant for specific Rab membrane targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

extracellular exosome

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

phagocytic vesicle membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

clathrin-coated vesicle membrane

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

10 references

8 April 2019

Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Biochemical characterization of APPL endosomes: the role of annexin A2 in APPL membrane recruitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Structural basis of Rab5-Rabaptin5 interaction in endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

postsynaptic early endosome

HDA

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

anchored component of synaptic vesicle membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

regulation of endocytosis

biological process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

regulation of filopodium assembly

1 reference

9 May 2017

Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

4 references

1 January 2018

Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20339&geneProductId=UniProtKB:P20339

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20339&geneProductId=UniProtKB:P20339

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20339&geneProductId=UniProtKB:P20339

1 January 2018

Structural basis of Rab5-Rabaptin5 interaction in endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20339&geneProductId=UniProtKB:P20339

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

receptor internalization involved in canonical Wnt signaling pathway

1 reference

8 April 2019

Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

regulation of autophagosome assembly

1 reference

8 April 2019

Regulation of autophagy by the Rab GTPase network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

synaptic vesicle recycling

1 reference

8 April 2019

Real-time imaging of Rab3a and Rab5a reveals differential roles in presynaptic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

early endosome to late endosome transport

IDA

1 reference

8 April 2019

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

1 reference

9 May 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

positive regulation of exocytosis

1 reference

8 April 2019

Rab27a and Rab27b control different steps of the exosome secretion pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

regulation of synaptic vesicle exocytosis

1 reference

8 April 2019

Real-time imaging of Rab3a and Rab5a reveals differential roles in presynaptic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

regulation of endosome size

1 reference

8 April 2019

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

viral RNA genome replication

1 reference

9 May 2017

Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P20339

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

phosphatidylinositol biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

membrane organization

1 reference

8 April 2019

post-translational protein modification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

intracellular protein transport

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

Rab protein signal transduction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

regulation of long-term neuronal synaptic plasticity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

amyloid-beta clearance by transcytosis

1 reference

8 April 2019

Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

5 references

8 April 2019

Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Structural basis of Rab5-Rabaptin5 interaction in endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20339

small GTP-binding protein domain

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20339

Identifiers

MeSH descriptor ID

D020696

subject named as

rab5 GTP-Binding Proteins

0 references

MeSH tree code

D08.811.277.040.330.300.400.400.200

0 references

D12.776.157.325.515.400.200

0 references

D12.776.476.338.400.400.200

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016