Proteasome 20S subunit alpha 3 (Q21111454)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25788

Proteasome subunit alpha 3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25788

Proteasome alpha-subunit, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

endopeptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25788&geneProductId=UniProtKB:P25788

1 reference

17 October 2017

peptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

protein binding

17 references

8 April 2019

A human protein-protein interaction network: a resource for annotating the proteome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

A directed protein interaction network for investigating intracellular signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

Crystal structure of the human 20S proteasome in complex with carfilzomib

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

Mapping and structural dissection of human 20 S proteasome using proteomic approaches

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

The alpha4 and alpha7 subunits and assembly of the 20S proteasome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

Toward an understanding of the protein interaction network of the human liver

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

Protein-protein interactions among human 20S proteasome subunits and proteassemblin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

The transcriptional repressor protein PRH interacts with the proteasome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

ubiquitin protein ligase binding

1 reference

8 April 2019

BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

cell component

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

proteasome complex

Structure and functions of the 20S and 26S proteasomes

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

8 April 2019

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

extracellular exosome

3 references

17 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25788&geneProductId=UniProtKB:P25788

17 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25788&geneProductId=UniProtKB:P25788

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25788&geneProductId=UniProtKB:P25788

nucleus

Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25788&geneProductId=UniProtKB:P25788

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25788&geneProductId=UniProtKB:P25788

17 October 2017

17 October 2017

Proteomic characterization of the human sperm nucleus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25788&geneProductId=UniProtKB:P25788

proteasome core complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25788&geneProductId=UniProtKB:P25788

3 references

17 October 2017

Ensembl genome database project

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25788&geneProductId=UniProtKB:P25788

17 October 2017

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25788&geneProductId=UniProtKB:P25788

synapse

Ensembl genome database project

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25788&geneProductId=UniProtKB:P25788

nucleus

Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

Proteomic characterization of the human sperm nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

HDA

cytoplasm

Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

proteasome core complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

4 references

8 April 2019

Ensembl genome database project

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

The ataxia protein sacsin is a functional co-chaperone that protects against polyglutamine-expanded ataxin-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

proteasome core complex, alpha-subunit complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

extracellular exosome

regulation of cellular amino acid metabolic process

HDA

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

regulation of mRNA stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

ubiquitin-dependent protein catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

positive regulation of canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

protein polyubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

stimulatory C-type lectin receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

tumor necrosis factor-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

proteolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

Fc-epsilon receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

NIK/NF-kappaB signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

anaphase-promoting complex-dependent catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

proteolysis involved in cellular protein catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

T cell receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

negative regulation of canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

regulation of endopeptidase activity

IMP

1 reference

8 April 2019

Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

IMP

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

Wnt signaling pathway, planar cell polarity pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

proteasome-mediated ubiquitin-dependent protein catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25788&geneProductId=UniProtKB:P25788

1 reference

17 October 2017

negative regulation of G2/M transition of mitotic cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

protein deubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

transmembrane transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

regulation of transcription from RNA polymerase II promoter in response to hypoxia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

post-translational protein modification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

regulation of hematopoietic stem cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

proteasomal protein catabolic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

proteasomal ubiquitin-independent protein catabolic process

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

proteasome-mediated ubiquitin-dependent protein catabolic process

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P25788&geneProductId=UniProtKB:P25788

interleukin-1-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

regulation of mitotic cell cycle phase transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P25788

1 reference

8 April 2019

physically interacts with

carfilzomib

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL451887

ixazomib

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2141296

Oprozomib

object of statement has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2103884

has part(s)

Proteasome alpha-subunit, N-terminal domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P25788

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016