Survival of motor neuron 2, centromeric (Q21111707)

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mammalian protein found in Homo sapiens
  • SMN1
  • survival motor neuron protein
  • survival of motor neuron 2 isoform D2A2B3457
  • component of gems 1
  • survival of motor neuron 2 isoform D347
  • survival of motor neuron 2 isoform D2B3457
  • survival of motor neuron 2 isoform D2A3457
  • survival of motor neuron 2 isoform D2A2B345
  • survival of motor neuron 2 isoform D3457
  • survival of motor neuron 2 isoform D345
  • gemin-1
  • tudor domain containing 16B
  • SMN2
  • Survival of Motor Neuron 1 Protein
edit
Language Label Description Also known as
English
Survival of motor neuron 2, centromeric
mammalian protein found in Homo sapiens
  • SMN1
  • survival motor neuron protein
  • survival of motor neuron 2 isoform D2A2B3457
  • component of gems 1
  • survival of motor neuron 2 isoform D347
  • survival of motor neuron 2 isoform D2B3457
  • survival of motor neuron 2 isoform D2A3457
  • survival of motor neuron 2 isoform D2A2B345
  • survival of motor neuron 2 isoform D3457
  • survival of motor neuron 2 isoform D345
  • gemin-1
  • tudor domain containing 16B
  • SMN2
  • Survival of Motor Neuron 1 Protein

Statements

molecular function
protein binding
determination method
IPI
26 references
retrieved
8 April 2019
stated in
Gemin8 is required for the architecture and function of the survival motor neuron complex
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
In vitro and in cellulo evidences for association of the survival of motor neuron complex with the fragile X mental retardation protein
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Dynamic protein-protein interaction wiring of the human spliceosome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
An orthogonal proteomic survey uncovers novel Zika virus host factors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
The SMN interactome includes Myb-binding protein 1a
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Stabilization of the survival motor neuron protein by ASK1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Coilin interacts with Ku proteins and inhibits in vitro non-homologous DNA end joining
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
identical protein binding
determination method
IPI
9 references
retrieved
8 April 2019
stated in
Dynamic protein-protein interaction wiring of the human spliceosome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
A novel nuclear structure containing the survival of motor neurons protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
Rpp20 interacts with SMN and is re-distributed into SMN granules in response to stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
The survival motor neuron protein forms soluble glycine zipper oligomers
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
retrieved
8 April 2019
stated in
The SMN interactome includes Myb-binding protein 1a
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IPI
cell component
gemini of coiled bodies
determination method
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IEA
retrieved
8 April 2019
stated in
A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IDA
retrieved
8 April 2019
stated in
Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IDA
retrieved
8 April 2019
stated in
A novel nuclear structure containing the survival of motor neurons protein
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IDA
retrieved
8 April 2019
stated in
Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IDA
retrieved
8 April 2019
stated in
Spinal muscular atrophy disrupts the interaction of ZPR1 with the SMN protein
GOA
curator
UniProt
UniProt protein ID
Q16637
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16637
determination method
IDA
biological process

Identifiers

MeSH descriptor ID
D055533
subject named as
Survival of Motor Neuron 1 Protein
0 references
Ensembl protein ID
 
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