Src kinase associated phosphoprotein 1 (Q21111718)

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mammalian protein found in Homo sapiens

src family-associated phosphoprotein 1
pp55
src kinase-associated phosphoprotein 1
SKAP-55
src kinase-associated phosphoprotein of 55 kDa
epididymis secretory sperm binding protein Li 81p
SKAP1

Language	Label	Description	Also known as
English	Src kinase associated phosphoprotein 1	mammalian protein found in Homo sapiens	src family-associated phosphoprotein 1 pp55 src kinase-associated phosphoprotein 1 SKAP-55 src kinase-associated phosphoprotein of 55 kDa epididymis secretory sperm binding protein Li 81p SKAP1

Statements

1 reference

13 November 2019

UniProt protein ID

SH3-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86WV1

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86WV1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86WV1

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Src kinase-associated phosphoprotein 1, SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

SH3 domain binding

determination method

1 reference

8 April 2019

SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

protein binding

determination method

5 references

8 April 2019

ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

8 April 2019

Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

8 April 2019

A novel S3S-TAP-tag for the isolation of T-cell interaction partners of adhesion and degranulation promoting adaptor protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

8 April 2019

Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

protein phosphatase binding

determination method

1 reference

8 April 2019

SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

protein kinase binding

determination method

1 reference

8 April 2019

Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

protein-containing complex binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

microtubule plus-end binding

determination method

1 reference

8 April 2019

Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

cell-cell junction

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

plasma membrane

determination method

4 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86WV1&geneProductId=UniProtKB:Q86WV1

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86WV1&geneProductId=UniProtKB:Q86WV1

determination method

24 April 2018

SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86WV1&geneProductId=UniProtKB:Q86WV1

determination method

24 April 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86WV1&geneProductId=UniProtKB:Q86WV1

determination method

T cell receptor complex

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

determination method

1 reference

8 April 2019

Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

immunological synapse

determination method

1 reference

8 April 2019

SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

8 April 2019

SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

plasma membrane

determination method

5 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

8 April 2019

SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

microtubule plus-end

determination method

1 reference

8 April 2019

Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

plasma membrane raft

determination method

1 reference

8 April 2019

SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

biological process

adaptive immune response

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

immune system process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

protein localization to plasma membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

T cell receptor signaling pathway

determination method

1 reference

8 April 2019

SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

positive regulation of cell adhesion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

positive regulation of transcription by RNA polymerase II

determination method

positive regulation of signal transduction

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

microtubule cytoskeleton organization

determination method

1 reference

8 April 2019

Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

positive regulation of cell-matrix adhesion

determination method

1 reference

8 April 2019

SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

positive regulation of adaptive immune response

determination method

1 reference

8 April 2019

SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

determination method

1 reference

8 April 2019

Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

positive regulation of integrin activation

determination method

1 reference

8 April 2019

SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

positive regulation of cell-cell adhesion mediated by integrin

determination method

1 reference

8 April 2019

SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

positive regulation of heterotypic cell-cell adhesion

determination method

1 reference

8 April 2019

SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

cellular response to epidermal growth factor stimulus

determination method

1 reference

8 April 2019

Signaling Scaffold Protein IQGAP1 Interacts with Microtubule Plus-end Tracking Protein SKAP and Links Dynamic Microtubule Plus-end to Steer Cell Migration.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

positive regulation of leukocyte cell-cell adhesion

determination method

1 reference

8 April 2019

SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86WV1

determination method

pleckstrin homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86WV1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86WV1

Src kinase-associated phosphoprotein 1, SH3 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86WV1

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000338171

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000338171

ENSP00000464311

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464311

ENSP00000462360

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462360

ENSP00000462437

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000462437

ENSP00000463284

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463284

ENSP00000464198

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464198

ENSP00000464509

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464509

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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