Eukaryotic translation initiation factor 5A (Q21112050)

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mammalian protein found in Homo sapiens

Eukaryotic initiation factor 5A isoform 1
eukaryotic initiation factor 5A
rev-binding factor
eIF-5A1
eukaryotic translation initiation factor 5A-1
EIF5A
eIF-5A
eIF-4D
eIF-5A-1

Language	Label	Description	Also known as
English	Eukaryotic translation initiation factor 5A	mammalian protein found in Homo sapiens	Eukaryotic initiation factor 5A isoform 1 eukaryotic initiation factor 5A rev-binding factor eIF-5A1 eukaryotic translation initiation factor 5A-1 EIF5A eIF-5A eIF-4D eIF-5A-1

Statements

1 reference

5 December 2018

UniProt protein ID

Translation elongation factor IF5A-like

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63241

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/I3L397

Ribosomal protein L2, domain 2

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63241

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/I3L397

Nucleic acid-binding, OB-fold

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63241

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/I3L397

Translation protein SH3-like domain superfamily

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63241

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/I3L397

animal nuclear pore complex

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Translation elongation factor, IF5A C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

2 references

5 December 2018

UniProt protein ID

UniProt protein ID

17 September 2016

2 references

5 December 2018

UniProt protein ID

UniProt protein ID

20 March 2016

language of work or name

molecular function

protein N-terminus binding

determination method

1 reference

9 May 2019

A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

translation elongation factor activity

determination method

protein binding

determination method

7 references

9 May 2019

Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

Nuclear pore localization and nucleocytoplasmic transport of eIF-5A: evidence for direct interaction with the export receptor CRM1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

Identification of the eukaryotic initiation factor 5A as a retinoic acid-stimulated cellular binding partner for tissue transglutaminase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

Specificity of the deoxyhypusine hydroxylase-eukaryotic translation initiation factor (eIF5A) interaction: identification of amino acid residues of the enzyme required for binding of its substrate, deoxyhypusine-containing eIF5A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

Identification and characterization of eukaryotic initiation factor 5A-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

determination method

4 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

26 September 2017

Identification of mRNA that binds to eukaryotic initiation factor 5A by affinity co-purification and differential display

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

26 September 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

U6 snRNA binding

determination method

1 reference

9 May 2019

Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

Identification of mRNA that binds to eukaryotic initiation factor 5A by affinity co-purification and differential display

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

translation elongation factor activity

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:I3L397

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

Subcellular localization of the hypusine-containing eukaryotic initiation factor 5A by immunofluorescent staining and green fluorescent protein tagging

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

endoplasmic reticulum membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

lamellae anulatae

determination method

1 reference

9 May 2019

Subcellular localization of the hypusine-containing eukaryotic initiation factor 5A by immunofluorescent staining and green fluorescent protein tagging

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

endoplasmic reticulum

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

extracellular exosome

determination method

1 reference

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

Subcellular localization of the hypusine-containing eukaryotic initiation factor 5A by immunofluorescent staining and green fluorescent protein tagging

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

9 May 2019

Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

neuronal cell body

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

biological process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

translational elongation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

mRNA export from nucleus

determination method

1 reference

9 May 2019

Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

peptidyl-lysine modification to peptidyl-hypusine

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

nucleocytoplasmic transport

determination method

protein export from nucleus

determination method

1 reference

9 May 2019

Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

positive regulation of cell population proliferation

determination method

1 reference

9 May 2019

Identification and characterization of eukaryotic initiation factor 5A-2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

protein transport

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63241

determination method

apoptotic process

determination method

positive regulation of cytosolic calcium ion concentration

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

positive regulation of cardiac muscle cell apoptotic process

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

positive regulation of apoptotic process

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

negative regulation of apoptotic process

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

positive regulation of muscle cell differentiation

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

cellular response to thyroid hormone stimulus

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

positive regulation of reactive oxygen species metabolic process

determination method

1 reference

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63241&geneProductId=UniProtKB:P63241

determination method

positive regulation of translational elongation

determination method

Translation elongation factor, IF5A C-terminal

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63241

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/I3L397

Translation elongation factor, IF5A, hypusine site

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P63241

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/I3L397

Identifiers

MeSH descriptor ID

subject named as

Eukaryotic Translation Initiation Factor 5A

0 references

D12.644.360.325.150.300.500

0 references

D12.776.476.325.150.300.500

0 references

D12.776.835.725.868.750.500

0 references

RefSeq protein ID

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

10 May 2019

1 reference

10 May 2019

UniProt protein ID

1 reference

5 December 2018

UniProt protein ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

Ensembl protein ID

ENSP00000336702

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000336702

ENSP00000336776

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000336776

ENSP00000390677

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000390677

ENSP00000396073

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000396073

ENSP00000458269

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000458269

ENSP00000459196

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000459196

ENSP00000459611

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000459611

ENSP00000460284

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000460284

ENSP00000461688

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000461688

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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