Protein phosphatase 1 regulatory subunit 12A (Q21112088)

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mammalian protein found in Homo sapiens

protein phosphatase 1, regulatory (inhibitor) subunit 12A
myosin phosphatase-targeting subunit 1
PPP1R12A
protein phosphatase 1 regulatory subunit 12A
myosin binding subunit
myosin phosphatase, target subunit 1
protein phosphatase myosin-binding subunit
Myosin phosphatase target subunit 1

Language	Label	Description	Also known as
English	Protein phosphatase 1 regulatory subunit 12A	mammalian protein found in Homo sapiens	protein phosphatase 1, regulatory (inhibitor) subunit 12A myosin phosphatase-targeting subunit 1 PPP1R12A protein phosphatase 1 regulatory subunit 12A myosin binding subunit myosin phosphatase, target subunit 1 protein phosphatase myosin-binding subunit Myosin phosphatase target subunit 1

Statements

1 reference

13 November 2019

UniProt protein ID

Protein phosphatase 1 regulatory subunit 12A/B/C

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14974

Ankyrin repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14974

Ankyrin repeat-containing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

cGMP-dependent protein kinase, interacting domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ankyrin repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

enzyme inhibitor activity

determination method

1 reference

17 October 2017

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14974&geneProductId=UniProtKB:O14974

determination method

14-3-3 protein binding

determination method

1 reference

8 April 2019

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

signal transducer activity

determination method

1 reference

17 October 2017

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14974&geneProductId=UniProtKB:O14974

determination method

protein binding

determination method

6 references

8 April 2019

Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

8 April 2019

Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

8 April 2019

Identification and characterization of zipper-interacting protein kinase as the unique vascular smooth muscle myosin phosphatase-associated kinase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

8 April 2019

A comprehensive resource of interacting protein regions for refining human transcription factor networks

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

8 April 2019

Phosphorylation-induced conformational switching of CPI-17 produces a potent myosin phosphatase inhibitor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

8 April 2019

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

phosphatase regulator activity

determination method

3 references

17 October 2017

Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14974&geneProductId=UniProtKB:O14974

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14974&geneProductId=UniProtKB:O14974

determination method

17 October 2017

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14974&geneProductId=UniProtKB:O14974

determination method

enzyme inhibitor activity

determination method

phosphatase regulator activity

determination method

4 references

8 April 2019

Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

8 April 2019

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

determination method

1 reference

8 April 2019

Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

determination method

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14974&geneProductId=UniProtKB:O14974

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

PTW/PP1 phosphatase complex

determination method

1 reference

8 April 2019

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

actin cytoskeleton

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

contractile fiber

determination method

1 reference

8 April 2019

Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

determination method

1 reference

8 April 2019

Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14974&geneProductId=UniProtKB:O14974

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

determination method

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

determination method

3 references

determination method

3 references

biological process

regulation of nucleocytoplasmic transport

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

positive regulation of myosin-light-chain-phosphatase activity

determination method

1 reference

17 October 2017

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14974&geneProductId=UniProtKB:O14974

determination method

negative regulation of catalytic activity

determination method

1 reference

8 April 2019

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

regulation of cell adhesion

determination method

1 reference

8 April 2019

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

G2/M transition of mitotic cell cycle

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

regulation of myosin-light-chain-phosphatase activity

determination method

1 reference

8 April 2019

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

regulation of establishment of endothelial barrier

determination method

1 reference

8 April 2019

Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

mitotic cell cycle

determination method

1 reference

8 April 2019

Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

centrosome cycle

determination method

1 reference

8 April 2019

Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14974

determination method

positive regulation of myosin-light-chain-phosphatase activity

determination method

ankyrin repeat-containing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14974

cGMP-dependent protein kinase, interacting domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14974

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14974

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000261207

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000261207

ENSP00000389168

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000389168

ENSP00000416769

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000416769

ENSP00000446855

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446855

ENSP00000449514

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449514

ENSP00000446816

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000446816

ENSP00000447144

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447144

ENSP00000447338

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000447338

ENSP00000449647

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449647

ENSP00000449666

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449666

ENSP00000449843

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000449843

ENSP00000450059

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450059

ENSP00000450061

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000450061

ENSP00000489242

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000489242

ENSP00000497229

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000497229

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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