Programmed cell death 6 (Q21112089)

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mammalian protein found in Homo sapiens
  • programmed cell death protein 6
  • probable calcium-binding protein ALG-2
  • PDCD6
  • apoptosis-linked gene 2 protein homolog
  • apoptosis-linked gene 2 protein
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Language Label Description Also known as
English
Programmed cell death 6
mammalian protein found in Homo sapiens
  • programmed cell death protein 6
  • probable calcium-binding protein ALG-2
  • PDCD6
  • apoptosis-linked gene 2 protein homolog
  • apoptosis-linked gene 2 protein

Statements

molecular function
calcium-dependent protein binding
determination method
IEA
IPI
7 references
retrieved
9 May 2019
stated in
ALG-2 oscillates in subcellular localization, unitemporally with calcium oscillations
GOA
curator
UniProt
UniProt protein ID
O75340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor
GOA
curator
UniProt
UniProt protein ID
O75340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants
GOA
curator
UniProt
UniProt protein ID
O75340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner
GOA
curator
UniProt
UniProt protein ID
O75340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I
GOA
curator
UniProt
UniProt protein ID
O75340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
The Ca2+-binding protein ALG-2 is recruited to endoplasmic reticulum exit sites by Sec31A and stabilizes the localization of Sec31A
GOA
curator
UniProt
UniProt protein ID
O75340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IEA
protein binding
determination method
IPI
18 references
retrieved
9 May 2019
stated in
Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants
GOA
curator
UniProt
UniProt protein ID
O75340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor
GOA
curator
UniProt
UniProt protein ID
O75340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
The calcium-binding protein ALG-2 promotes endoplasmic reticulum exit site localization and polymerization of Trk-fused gene (TFG) protein
GOA
curator
UniProt
UniProt protein ID
O75340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
Structural and Functional Study of Apoptosis-linked Gene-2·Heme-binding Protein 2 Interactions in HIV-1 Production
GOA
curator
UniProt
UniProt protein ID
O75340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
VPS37 isoforms differentially modulate the ternary complex formation of ALIX, ALG-2, and ESCRT-I
GOA
curator
UniProt
UniProt protein ID
O75340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
Structural analysis of the complex between penta-EF-hand ALG-2 protein and Sec31A peptide reveals a novel target recognition mechanism of ALG-2
GOA
curator
UniProt
UniProt protein ID
O75340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
ALG-2 interacts with the amino-terminal domain of annexin XI in a Ca(2+)-dependent manner
GOA
curator
UniProt
UniProt protein ID
O75340
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
HD-PTP and Alix share some membrane-traffic related proteins that interact with their Bro1 domains or proline-rich regions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
retrieved
9 May 2019
stated in
Programmed cell death 6 (PDCD6) protein interacts with death-associated protein kinase 1 (DAPk1): additive effect on apoptosis via caspase-3 dependent pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75340
determination method
IPI
cell component
biological process

Identifiers

 
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