Ubiquitin specific peptidase 22 (Q21112578)

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mammalian protein found in Homo sapiens

ubiquitin thiolesterase 22
USP22
Ubiquitin-specific-processing protease 22
deubiquitinating enzyme 22
ubiquitin specific protease 22
ubiquitin-specific processing protease 22
ubiquitin thioesterase 22
ubiquitin carboxyl-terminal hydrolase 22

Language	Label	Description	Also known as
English	Ubiquitin specific peptidase 22	mammalian protein found in Homo sapiens	ubiquitin thiolesterase 22 USP22 Ubiquitin-specific-processing protease 22 deubiquitinating enzyme 22 ubiquitin specific protease 22 ubiquitin-specific processing protease 22 ubiquitin thioesterase 22 ubiquitin carboxyl-terminal hydrolase 22

Statements

1 reference

13 November 2019

UniProt protein ID

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UPT9

Papain-like cysteine peptidase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UPT9

Peptidase C19, ubiquitin carboxyl-terminal hydrolase family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, UBP-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin specific protease domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin specific protease, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

cysteine-type peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

transcription coactivator activity

determination method

1 reference

8 April 2019

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

zinc ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

H4 histone acetyltransferase activity

determination method

1 reference

8 April 2019

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

protein binding

determination method

6 references

8 April 2019

Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

8 April 2019

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

8 April 2019

Defining the human deubiquitinating enzyme interaction landscape

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

8 April 2019

USP22 is a positive regulator of NFATc2 on promoting IL2 expression

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

8 April 2019

USP22 regulates cell proliferation by deubiquitinating the transcriptional regulator FBP1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

nuclear receptor coactivator activity

determination method

1 reference

8 April 2019

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

thiol-dependent deubiquitinase

determination method

3 references

8 April 2019

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

8 April 2019

The expression patterns of deubiquitinating enzymes, USP22 and Usp22

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

determination method

1 reference

8 April 2019

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

thiol-dependent deubiquitinase

determination method

3 references

SAGA-type complex

determination method

1 reference

8 April 2019

Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

determination method

3 references

8 April 2019

Cytoplasmic ATXN7L3B Interferes with Nuclear Functions of the SAGA Deubiquitinase Module

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

8 April 2019

A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

8 April 2019

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

biological process

regulation of transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPT9&geneProductId=UniProtKB:Q9UPT9

determination method

ubiquitin-dependent protein catabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

positive regulation of mitotic cell cycle

determination method

1 reference

8 April 2019

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UPT9&geneProductId=UniProtKB:Q9UPT9

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

histone deubiquitination

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

histone ubiquitination

determination method

1 reference

8 April 2019

USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

histone H4 acetylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

protein deubiquitination

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

8 April 2019

The expression patterns of deubiquitinating enzymes, USP22 and Usp22

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

embryo development ending in birth or egg hatching

determination method

1 reference

8 April 2019

The expression patterns of deubiquitinating enzymes, USP22 and Usp22

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

chromatin organization

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UPT9

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000261497

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000261497

ENSP00000440950

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000440950

ENSP00000464398

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464398

ENSP00000464499

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464499

ENSP00000468457

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468457

ENSP00000468748

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468748

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Multilingual sites(0 entries)

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