Protein phosphatase 3 regulatory subunit B, alpha (Q21112913)

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mammalian protein found in Homo sapiens
  • Protein phosphatase 3 regulatory subunit B alpha isoform 1
  • protein phosphatase 2B regulatory subunit 1
  • calcineurin B, type I (19kDa)
  • calcineurin subunit B type 1
  • protein phosphatase 2B regulatory subunit B alpha
  • PPP3R1
  • protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)
  • protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)
  • protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform
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Language Label Description Also known as
English
Protein phosphatase 3 regulatory subunit B, alpha
mammalian protein found in Homo sapiens
  • Protein phosphatase 3 regulatory subunit B alpha isoform 1
  • protein phosphatase 2B regulatory subunit 1
  • calcineurin B, type I (19kDa)
  • calcineurin subunit B type 1
  • protein phosphatase 2B regulatory subunit B alpha
  • PPP3R1
  • protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)
  • protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)
  • protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform

Statements

molecular function
protein binding
determination method
IPI
11 references
retrieved
8 April 2019
stated in
Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
GOA
curator
UniProt
UniProt protein ID
P63098
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life
GOA
curator
UniProt
UniProt protein ID
P63098
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IPI
retrieved
8 April 2019
stated in
WITHDRAWN: USP14 stabilizes calcineurin and regulates NFAT/AP-1 dependent IL-4 transcription as a novel calcineurin-binding protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IPI
retrieved
8 April 2019
stated in
Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IPI
retrieved
8 April 2019
stated in
The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IPI
retrieved
8 April 2019
stated in
The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IPI
retrieved
8 April 2019
stated in
Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IPI
retrieved
8 April 2019
stated in
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IPI
cell component
calcineurin complex
determination method
IDA
IEA
NAS
9 references
retrieved
24 April 2018
stated in
Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase
GOA
curator
UniProt
UniProt protein ID
P63098
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63098&geneProductId=UniProtKB:P63098
determination method
NAS
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63098&geneProductId=UniProtKB:P63098
determination method
IEA
retrieved
24 April 2018
stated in
Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
GOA
curator
UniProt
UniProt protein ID
P63098
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63098&geneProductId=UniProtKB:P63098
determination method
IDA
retrieved
24 April 2018
stated in
The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin
GOA
curator
UniProt
UniProt protein ID
P63098
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63098&geneProductId=UniProtKB:P63098
determination method
IDA
retrieved
24 April 2018
stated in
Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM.
GOA
curator
UniProt
UniProt protein ID
P63098
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63098&geneProductId=UniProtKB:P63098
determination method
IDA
retrieved
24 April 2018
stated in
Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling
GOA
curator
UniProt
UniProt protein ID
P63098
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63098&geneProductId=UniProtKB:P63098
determination method
IDA
retrieved
24 April 2018
stated in
Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
GOA
curator
UniProt
UniProt protein ID
P63098
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63098&geneProductId=UniProtKB:P63098
determination method
IDA
retrieved
24 April 2018
stated in
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63098&geneProductId=UniProtKB:P63098
determination method
IDA
retrieved
24 April 2018
stated in
Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P63098&geneProductId=UniProtKB:P63098
determination method
IDA
calcineurin complex
determination method
IDA
NAS
8 references
retrieved
8 April 2019
stated in
Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase
GOA
curator
UniProt
UniProt protein ID
P63098
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
NAS
retrieved
8 April 2019
stated in
Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM.
GOA
curator
UniProt
UniProt protein ID
P63098
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IDA
retrieved
8 April 2019
stated in
Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
GOA
curator
UniProt
UniProt protein ID
P63098
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IDA
retrieved
8 April 2019
stated in
The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin
GOA
curator
UniProt
UniProt protein ID
P63098
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IDA
retrieved
8 April 2019
stated in
Balanced interactions of calcineurin with AKAP79 regulate Ca2+–calcineurin–NFAT signaling
GOA
curator
UniProt
UniProt protein ID
P63098
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IDA
retrieved
8 April 2019
stated in
Cooperative autoinhibition and multi-level activation mechanisms of calcineurin
GOA
curator
UniProt
UniProt protein ID
P63098
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IDA
retrieved
8 April 2019
stated in
Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IDA
retrieved
8 April 2019
stated in
Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63098
determination method
IDA
biological process

Identifiers

 
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