Ubiquitin like modifier activating enzyme 5 (Q21113334)

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mammalian protein found in Homo sapiens

UBA5, ubiquitin-activating enzyme E1 homolog
ubiquitin-activating enzyme E1-domain containing 1
UBA5
UFM1-activating enzyme
ubiquitin-activating enzyme 5
ubiquitin-activating enzyme E1 domain-containing protein 1
ThiFP1
ubiquitin-like modifier-activating enzyme 5

Language	Label	Description	Also known as
English	Ubiquitin like modifier activating enzyme 5	mammalian protein found in Homo sapiens	UBA5, ubiquitin-activating enzyme E1 homolog ubiquitin-activating enzyme E1-domain containing 1 UBA5 UFM1-activating enzyme ubiquitin-activating enzyme 5 ubiquitin-activating enzyme E1 domain-containing protein 1 ThiFP1 ubiquitin-like modifier-activating enzyme 5

Statements

1 reference

13 November 2019

UniProt protein ID

ubiquitin-activating enzyme

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9GZZ9

THIF-type NAD/FAD binding fold, protein family

1 reference

based on heuristic

inferred from protein domain or family

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

protein binding

determination method

6 references

8 April 2019

Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

UBA5 Mutations Cause a New Form of Autosomal Recessive Cerebellar Ataxia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

Network organization of the human autophagy system

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

A directed protein interaction network for investigating intracellular signal transduction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

ubiquitin-like modifier activating enzyme activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

UFM1 activating enzyme activity

determination method

3 references

5 June 2018

Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ9&geneProductId=UniProtKB:Q9GZZ9

determination method

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ9&geneProductId=UniProtKB:Q9GZZ9

determination method

5 June 2018

A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ9&geneProductId=UniProtKB:Q9GZZ9

determination method

UFM1 activating enzyme activity

determination method

4 references

8 April 2019

Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

determination method

3 references

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ9&geneProductId=UniProtKB:Q9GZZ9

determination method

5 June 2018

UBA5 Mutations Cause a New Form of Autosomal Recessive Cerebellar Ataxia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ9&geneProductId=UniProtKB:Q9GZZ9

determination method

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ9&geneProductId=UniProtKB:Q9GZZ9

determination method

intracellular membrane-bounded organelle

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

determination method

1 reference

10 September 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ9&geneProductId=UniProtKB:Q9GZZ9

determination method

Golgi apparatus

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

UBA5 Mutations Cause a New Form of Autosomal Recessive Cerebellar Ataxia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

biological process

regulation of intracellular estrogen receptor signaling pathway

determination method

1 reference

8 April 2019

Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

protein K69-linked ufmylation

determination method

1 reference

8 April 2019

Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

response to endoplasmic reticulum stress

determination method

1 reference

8 April 2019

Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

protein ufmylation

determination method

4 references

5 June 2018

Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ9&geneProductId=UniProtKB:Q9GZZ9

determination method

5 June 2018

Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ9&geneProductId=UniProtKB:Q9GZZ9

determination method

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ9&geneProductId=UniProtKB:Q9GZZ9

determination method

5 June 2018

A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9GZZ9&geneProductId=UniProtKB:Q9GZZ9

determination method

neuromuscular process

determination method

1 reference

8 April 2019

UBA5 Mutations Cause a New Form of Autosomal Recessive Cerebellar Ataxia

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

protein ufmylation

determination method

5 references

8 April 2019

Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

Transcriptional regulation of the Ufm1 conjugation system in response to disturbance of the endoplasmic reticulum homeostasis and inhibition of vesicle trafficking

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

protein modification by small protein conjugation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9GZZ9

determination method

THIF-type NAD/FAD binding fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9GZZ9

D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9GZZ9

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000264991

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000264991

ENSP00000348565

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000348565

ENSP00000418807

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418807

ENSP00000417879

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417879

ENSP00000417905

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000417905

ENSP00000418569

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418569

ENSP00000420055

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000420055

ENSP00000424984

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424984

ENSP00000427233

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427233

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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