Protein kinase D2 (Q21113377)

PH-like domain superfamily

1 reference

protein kinase C mu-related

1 reference

pleckstrin homology domain, protein family

1 reference

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

Diacylglycerol/phorbol-ester binding domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

2 references

protein serine/threonine kinase activity

5 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZL6&geneProductId=UniProtKB:Q9BZL6

10 September 2018

Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZL6&geneProductId=UniProtKB:Q9BZL6

10 September 2018

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZL6&geneProductId=UniProtKB:Q9BZL6

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZL6&geneProductId=UniProtKB:Q9BZL6

10 September 2018

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZL6&geneProductId=UniProtKB:Q9BZL6

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop

protein kinase C binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

protein serine/threonine kinase activity

IPI

4 references

8 April 2019

Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

8 April 2019

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

positive regulation of vascular endothelial growth factor receptor signaling pathway

biological process

1 reference

8 April 2019

Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

intracellular signal transduction

3 references

8 April 2019

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

positive regulation of endothelial cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

adaptive immune response

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

immune system process

1 reference

8 April 2019

endothelial tube morphogenesis

1 reference

8 April 2019

Protein kinase D in vascular biology and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

positive regulation of fibroblast growth factor receptor signaling pathway

TAS

1 reference

8 April 2019

Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

positive regulation of endothelial cell chemotaxis

1 reference

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

positive regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

PKD2 interacts with Lck and regulates NFAT activity in T cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

1 reference

8 April 2019

Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

protein kinase D signaling

1 reference

27 March 2018

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BZL6&geneProductId=UniProtKB:Q9BZL6

positive regulation of intracellular signal transduction

1 reference

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

positive regulation of peptidyl-serine phosphorylation

1 reference

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

positive regulation of angiogenesis

3 references

8 April 2019

Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

positive regulation of endothelial cell migration

1 reference

8 April 2019

Identification of protein kinase D2 as a pivotal regulator of endothelial cell proliferation, migration, and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases

protein phosphorylation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

8 April 2019

Protein kinase D regulates RhoA activity via rhotekin phosphorylation

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

positive regulation of histone deacetylase activity

1 reference

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

positive regulation of CREB transcription factor activity

1 reference

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

vascular endothelial growth factor receptor signaling pathway

1 reference

8 April 2019

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

positive regulation of NF-kappaB transcription factor activity

3 references

8 April 2019

Protein kinase D2 mediates activation of nuclear factor kappaB by Bcr-Abl in Bcr-Abl+ human myeloid leukemia cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

8 April 2019

Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

8 April 2019

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

positive regulation of interleukin-8 production

1 reference

8 April 2019

Protein kinase D2 mediates lysophosphatidic acid-induced interleukin 8 production in nontransformed human colonic epithelial cells through NF-kappaB

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

positive regulation of blood vessel endothelial cell migration

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

cellular response to vascular endothelial growth factor stimulus

3 references

8 April 2019

The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

8 April 2019

Vascular endothelial growth factor induces heat shock protein (HSP) 27 serine 82 phosphorylation and endothelial tubulogenesis via protein kinase D and independent of p38 kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

8 April 2019

Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

T cell receptor signaling pathway

1 reference

8 April 2019

Protein kinase D2 contributes to either IL-2 promoter regulation or induction of cell death upon TCR stimulation depending on its activity in Jurkat cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

positive regulation of transcription by RNA polymerase II

positive regulation of cell adhesion

1 reference

8 April 2019

Angiotensin II directly triggers endothelial exocytosis via protein kinase C-dependent protein kinase D2 activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

sphingolipid biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

peptidyl-serine phosphorylation

TAS

peptidyl-threonine phosphorylation

2 references

1 reference

8 April 2019

Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BZL6

pleckstrin homology domain

has part(s)

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

serine/threonine-protein kinase, active site

1 reference

diacylglycerol/phorbol-ester binding

1 reference

D08.811.913.696.620.682.700.750

Identifiers

MeSH descriptor ID

D000091283

subject named as

Protein Kinase D2

0 references

MeSH tree code

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference