Cell division cycle 73 (Q21113887)

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mammalian protein found in Homo sapiens
  • CDC73
  • cell division cycle 73, Paf1/RNA polymerase II complex component, homolog
  • Familial isolated hyperparathyroidism
  • cell division cycle 73 Paf1/RNA polymerase II complex component-like protein
  • Paf1/RNA polymerase II complex component
  • cell division cycle protein 73 homolog
  • parafibromin
  • hyperparathyroidism 2 protein
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Language Label Description Also known as
English
Cell division cycle 73
mammalian protein found in Homo sapiens
  • CDC73
  • cell division cycle 73, Paf1/RNA polymerase II complex component, homolog
  • Familial isolated hyperparathyroidism
  • cell division cycle 73 Paf1/RNA polymerase II complex component-like protein
  • Paf1/RNA polymerase II complex component
  • cell division cycle protein 73 homolog
  • parafibromin
  • hyperparathyroidism 2 protein

Statements

molecular function
protein binding
determination method
IPI
15 references
retrieved
8 April 2019
stated in
Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling
GOA
curator
UniProt
UniProt protein ID
Q6P1J9
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
retrieved
8 April 2019
stated in
A directed protein interaction network for investigating intracellular signal transduction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
retrieved
8 April 2019
stated in
RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
retrieved
8 April 2019
stated in
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
retrieved
8 April 2019
stated in
BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
retrieved
8 April 2019
stated in
The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
retrieved
8 April 2019
stated in
Widespread macromolecular interaction perturbations in human genetic disorders
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
retrieved
8 April 2019
stated in
PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
retrieved
8 April 2019
stated in
The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
retrieved
8 April 2019
stated in
The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
retrieved
8 April 2019
stated in
The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
retrieved
8 April 2019
stated in
The human PAF complex coordinates transcription with events downstream of RNA synthesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
retrieved
8 April 2019
stated in
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6P1J9
determination method
IPI
cell component
biological process

Identifiers

 
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