ETS proto-oncogene 2, transcription factor (Q21114062)

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mammalian protein found in Homo sapiens

protein C-ets-2
v-ets erythroblastosis virus E26 oncogene homolog 2
oncogene ETS-2
v-ets avian erythroblastosis virus E2 oncogene homolog 2
ETS2
v-ets avian erythroblastosis virus E26 oncogene homolog 2

Language	Label	Description	Also known as
English	ETS proto-oncogene 2, transcription factor	mammalian protein found in Homo sapiens	protein C-ets-2 v-ets erythroblastosis virus E26 oncogene homolog 2 oncogene ETS-2 v-ets avian erythroblastosis virus E2 oncogene homolog 2 ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2

Statements

1 reference

5 December 2018

UniProt protein ID

Winged helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15036

transforming protein C-ets-2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15036

Winged helix-like DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15036

Sterile alpha motif/pointed domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15036

ETS transcription factor family

1 reference

based on heuristic

inferred from protein domain or family

Pointed domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

5 December 2018

UniProt protein ID

1 reference

5 December 2018

UniProt protein ID

molecular function

determination method

3 references

8 April 2019

Hepatitis B virus-X protein upregulates the expression of p21waf1/cip1 and prolongs G1-->S transition via a p53-independent pathway in human hepatoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

RNA polymerase II transcription regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

DNA-binding transcription factor activity

determination method

3 references

8 April 2019

Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

Sp100 interacts with ETS-1 and stimulates its transcriptional activity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

8 April 2019

Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

DNA-binding transcription repressor activity, RNA polymerase II-specific

determination method

2 references

17 October 2017

Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15036&geneProductId=UniProtKB:P15036

determination method

8 April 2019

Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

protein binding

determination method

6 references

8 April 2019

Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

Identification of CDK10 as an important determinant of resistance to endocrine therapy for breast cancer

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

Sp100 interacts with ETS-1 and stimulates its transcriptional activity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

glucocorticoid receptor binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

protein domain specific binding

determination method

1 reference

8 April 2019

A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

4 references

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

plasma membrane

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

determination method

3 references

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15036&geneProductId=UniProtKB:P15036

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15036&geneProductId=UniProtKB:P15036

determination method

17 October 2017

Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15036&geneProductId=UniProtKB:P15036

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

8 April 2019

Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

biological process

skeletal system development

determination method

1 reference

8 April 2019

Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

cell differentiation

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

transcription, DNA-templated

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P15036&geneProductId=UniProtKB:P15036

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Sp100 interacts with ETS-1 and stimulates its transcriptional activity

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

ectodermal cell fate commitment

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

mesoderm development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

primitive streak formation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15036

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15036

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15036

Identifiers

RefSeq protein ID

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

1 reference

7 December 2018

UniProt protein ID

1 reference

5 December 2018

UniProt protein ID

Ensembl protein ID

ENSP00000353344

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000353344

ENSP00000354194

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000354194

ENSP00000401273

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000401273

ENSP00000411086

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000411086

PDB structure ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

1 reference

UniProt protein ID

20 March 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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