Cell division cycle 25C (Q21114065)

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mammalian protein found in Homo sapiens

CDC25C
mitosis inducer CDC25
M-phase inducer phosphatase 3
phosphotyrosine phosphatase
dual specificity phosphatase CDC25C
protein phosphatase 1, regulatory subunit 60

Language	Label	Description	Also known as
English	Cell division cycle 25C	mammalian protein found in Homo sapiens	CDC25C mitosis inducer CDC25 M-phase inducer phosphatase 3 phosphotyrosine phosphatase dual specificity phosphatase CDC25C protein phosphatase 1, regulatory subunit 60

Statements

1 reference

13 November 2019

UniProt protein ID

Rhodanese-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30307

M-phase inducer phosphatase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30307

Rhodanese-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

9 references

8 April 2019

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

Chaperoning checkpoint kinase 1 (Chk1), an Hsp90 client, with purified chaperones

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

WW domain binding

determination method

1 reference

8 April 2019

Function of WW domains as phosphoserine- or phosphothreonine-binding modules

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

protein tyrosine phosphatase activity

determination method

3 references

27 February 2018

An additional transcript of the cdc25C gene from A431 cells encodes a functional protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30307&geneProductId=UniProtKB:P30307

determination method

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30307&geneProductId=UniProtKB:P30307

determination method

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30307&geneProductId=UniProtKB:P30307

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

protein tyrosine phosphatase activity

determination method

4 references

8 April 2019

An additional transcript of the cdc25C gene from A431 cells encodes a functional protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

phosphoprotein phosphatase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

determination method

1 reference

27 February 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30307&geneProductId=UniProtKB:P30307

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

intracellular anatomical structure

determination method

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30307&geneProductId=UniProtKB:P30307

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

perinuclear region of cytoplasm

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

determination method

3 references

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30307&geneProductId=UniProtKB:P30307

determination method

27 February 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30307&geneProductId=UniProtKB:P30307

determination method

27 February 2018

Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30307&geneProductId=UniProtKB:P30307

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

biological process

regulation of cyclin-dependent protein serine/threonine kinase activity

determination method

1 reference

8 April 2019

Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

protein dephosphorylation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

regulation of cell cycle

determination method

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30307&geneProductId=UniProtKB:P30307

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

DNA replication

determination method

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30307&geneProductId=UniProtKB:P30307

determination method

spermatogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

regulation of mitotic nuclear division

determination method

1 reference

8 April 2019

Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

peptidyl-tyrosine dephosphorylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

positive regulation of cell cycle G2/M phase transition

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

G2/M transition of mitotic cell cycle

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

positive regulation of G2/M transition of mitotic cell cycle

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

positive regulation of mitotic cell cycle

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

positive regulation of G2/MI transition of meiotic cell cycle

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30307

determination method

Rhodanese-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30307

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000321656

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000321656

ENSP00000345205

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000345205

ENSP00000392631

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000392631

ENSP00000424795

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000424795

ENSP00000425470

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000425470

ENSP00000423525

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000423525

ENSP00000427105

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427105

ENSP00000427251

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000427251

ENSP00000497591

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000497591

PDB structure ID

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

1 reference

UniProt protein ID

5 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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