Hepatocyte nuclear factor 4 alpha (Q21114166)

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mammalian protein found in Homo sapiens

hepatic nuclear factor 4 alpha
nuclear receptor subfamily 2 group A member 1
hepatocyte nuclear factor 4-alpha
transcription factor 14
TCF-14
transcription factor HNF-4
HNF4A
HNF4alpha10/11/12

Language	Label	Description	Also known as
English	Hepatocyte nuclear factor 4 alpha	mammalian protein found in Homo sapiens	hepatic nuclear factor 4 alpha nuclear receptor subfamily 2 group A member 1 hepatocyte nuclear factor 4-alpha transcription factor 14 TCF-14 transcription factor HNF-4 HNF4A HNF4alpha10/11/12

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

5 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Mitogen-activated protein kinase regulates transcription of the ApoCIII gene. Involvement of the orphan nuclear receptor HNF4

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

DNA-binding transcription factor activity

determination method

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Regulation of alpha1-antitrypsin gene expression in human intestinal epithelial cell line caco-2 by HNF-1alpha and HNF-4

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

1 reference

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235

determination method

zinc ion binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method

1 reference

21 June 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

steroid hormone receptor activity

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

nuclear receptor activity

determination method

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235

determination method

protein binding

determination method

11 references

9 May 2019

Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Functional dissection of the alpha-synuclein promoter: transcriptional regulation by ZSCAN21 and ZNF219

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Cited2, a coactivator of HNF4alpha, is essential for liver development

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Transcription of the human microsomal epoxide hydrolase gene (EPHX1) is regulated by an HNF-4α/CAR/RXR/PSF complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

determination method

1 reference

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235

determination method

signaling receptor binding

determination method

1 reference

9 May 2019

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

fatty acid binding

determination method

1 reference

9 May 2019

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

protein homodimerization activity

determination method

1 reference

9 May 2019

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

3 references

21 June 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235

determination method

21 June 2018

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235

determination method

21 June 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

4 references

9 May 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

A census of human transcription factors: function, expression and evolution

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

determination method

6 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

A Crucial Role of Hepatocyte Nuclear Factor-4 Expression in the Differentiation of Human Ductular Hepatocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

determination method

1 reference

9 May 2019

A Crucial Role of Hepatocyte Nuclear Factor-4 Expression in the Differentiation of Human Ductular Hepatocytes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

biological process

ornithine metabolic process

determination method

1 reference

9 May 2019

Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

SMAD protein signal transduction

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

lipid metabolism

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

regulation of transcription by RNA polymerase II

determination method

4 references

9 May 2019

HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Regulation of alpha1-antitrypsin gene expression in human intestinal epithelial cell line caco-2 by HNF-1alpha and HNF-4

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

signal transduction involved in regulation of gene expression

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

sex differentiation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

blood coagulation

determination method

1 reference

9 May 2019

Functional characterization of transcription factor binding sites for HNF1-alpha, HNF3-beta (FOXA2), HNF4-alpha, Sp1 and Sp3 in the human prothrombin gene enhancer

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

transcription, DNA-templated

determination method

1 reference

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235

determination method

regulation of lipid metabolic process

determination method

1 reference

9 May 2019

Mitogen-activated protein kinase regulates transcription of the ApoCIII gene. Involvement of the orphan nuclear receptor HNF4

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

intracellular receptor signaling pathway

determination method

1 reference

7 November 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235

determination method

regulation of growth hormone receptor signaling pathway

determination method

1 reference

21 June 2018

Expression of the hepatic specific V1 messenger ribonucleic acid of the human growth hormone receptor gene is regulated by hepatic nuclear factor (HNF)-4alpha2 and HNF-4alpha8

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235

determination method

negative regulation of cell growth

determination method

1 reference

9 May 2019

HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

lipid homeostasis

determination method

1 reference

24 April 2018

Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41235&geneProductId=UniProtKB:P41235

determination method

xenobiotic metabolic process

determination method

1 reference

9 May 2019

Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

transcription initiation from RNA polymerase II promoter

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

regulation of gastrulation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

steroid hormone mediated signaling pathway

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

positive regulation of transcription by RNA polymerase II

determination method

4 references

9 May 2019

HNF4A Regulates the Formation of Hepatic Progenitor Cells from Human iPSC-Derived Endoderm by Facilitating Efficient Recruitment of RNA Pol II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

9 May 2019

Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

negative regulation of cell population proliferation

determination method

1 reference

9 May 2019

HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

type B pancreatic cell development

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

hepatocyte differentiation

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

negative regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

rhythmic process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41235

determination method

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

http://purl.uniprot.org/uniprot/P41235

1 reference

Identifiers.org

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000312987

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000312987

ENSP00000315180

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000315180

ENSP00000396216

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000396216

ENSP00000410911

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000410911

ENSP00000412111

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412111

ENSP00000476609

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000476609

ENSP00000362011

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362011

ENSP00000476310

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000476310

ENSP00000481331

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000481331

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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