VRK serine/threonine kinase 2 (Q21114346)

http://www.ebi.ac.uk/interpro/protein/Q86Y07

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

protein kinase activity

1 reference

8 April 2019

protein domain specific binding

1 reference

8 April 2019

Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

protein serine/threonine kinase activity

6 references

10 September 2018

Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Y07&geneProductId=UniProtKB:Q86Y07

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Y07&geneProductId=UniProtKB:Q86Y07

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Y07&geneProductId=UniProtKB:Q86Y07

10 September 2018

The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Y07&geneProductId=UniProtKB:Q86Y07

10 September 2018

Characterization of three paralogous members of the Mammalian vaccinia related kinase family

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Y07&geneProductId=UniProtKB:Q86Y07

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Y07&geneProductId=UniProtKB:Q86Y07

3 references

8 April 2019

VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

Human cellular protein VRK2 interacts specifically with Epstein-Barr virus BHRF1, a homologue of Bcl-2, and enhances cell survival

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

2 references

protein kinase binding

1 reference

8 April 2019

Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

protein serine/threonine kinase activity

IDA

7 references

8 April 2019

Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

Characterization of three paralogous members of the Mammalian vaccinia related kinase family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

integral component of membrane

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

endoplasmic reticulum

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

protein-containing complex

1 reference

8 April 2019

Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

regulation of MAPK cascade

biological process

1 reference

8 April 2019

VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

regulation of interleukin-1-mediated signaling pathway

IMP

1 reference

8 April 2019

Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase

protein phosphorylation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

peptidyl-serine phosphorylation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

protein autophosphorylation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

Characterization of three paralogous members of the Mammalian vaccinia related kinase family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

8 April 2019

The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

cellular response to oxidative stress

IDA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86Y07&geneProductId=UniProtKB:Q86Y07

regulation of cell shape

1 reference

27 March 2018

peptidyl-threonine phosphorylation

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86Y07

serine/threonine-protein kinase, active site

EC enzyme number

2.7.11.1

0 references

has part(s)

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86Y07

protein kinase domain

1 reference

stated in

InterPro Release 71.0