Ubiquitin specific peptidase 18 (Q21114727)

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mammalian protein found in Homo sapiens

ubl thioesterase 18
hUBP43
ubl carboxyl-terminal hydrolase 18
43 kDa ISG15-specific protease
USP18
ubl thiolesterase 18
ISG15-specific-processing protease
ubiquitin specific protease 18

Language	Label	Description	Also known as
English	Ubiquitin specific peptidase 18	mammalian protein found in Homo sapiens	ubl thioesterase 18 hUBP43 ubl carboxyl-terminal hydrolase 18 43 kDa ISG15-specific protease USP18 ubl thiolesterase 18 ISG15-specific-processing protease ubiquitin specific protease 18

Statements

1 reference

13 November 2019

UniProt protein ID

Papain-like cysteine peptidase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UMW8

Peptidase C19, ubiquitin carboxyl-terminal hydrolase family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin specific protease domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin specific protease, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

USP18.png
1,920 × 975; 757 KB

0 references

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMW8

determination method

cysteine-type peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMW8

determination method

protein binding

determination method

4 references

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMW8

determination method

8 April 2019

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMW8

determination method

8 April 2019

UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMW8

determination method

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMW8

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMW8

determination method

thiol-dependent deubiquitinase

determination method

1 reference

24 April 2018

Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18)

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMW8&geneProductId=UniProtKB:Q9UMW8

determination method

ISG15-specific protease activity

determination method

1 reference

10 September 2018

UBP43 (USP18) specifically removes ISG15 from conjugated proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UMW8&geneProductId=UniProtKB:Q9UMW8

determination method

cysteine-type endopeptidase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMW8

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMW8

determination method

determination method

3 references

determination method

biological process

regulation of type I interferon-mediated signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMW8

determination method

ubiquitin-dependent protein catabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMW8

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMW8

determination method

regulation of inflammatory response

determination method

1 reference

8 April 2019

Human USP18 deficiency underlies type 1 interferonopathy leading to severe pseudo-TORCH syndrome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMW8

determination method

protein deubiquitination

determination method

regulation of protein stability

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UMW8

determination method

Ubiquitin specific protease domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UMW8

Ubiquitin specific protease, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UMW8

Peptidase C19, ubiquitin carboxyl-terminal hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UMW8

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000215794

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000215794

PDB structure ID

0 references

0 references

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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