Interferon stimulated exonuclease gene 20 (Q21114780)

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mammalian protein found in Homo sapiens

promyelocytic leukemia nuclear body-associated protein ISG20
interferon-stimulated gene 20 kDa protein
ISG20
estrogen-regulated transcript 45 protein
interferon stimulated exonuclease gene 20kDa

Language	Label	Description	Also known as
English	Interferon stimulated exonuclease gene 20	mammalian protein found in Homo sapiens	promyelocytic leukemia nuclear body-associated protein ISG20 interferon-stimulated gene 20 kDa protein ISG20 estrogen-regulated transcript 45 protein interferon stimulated exonuclease gene 20kDa

Statements

1 reference

13 November 2019

UniProt protein ID

Ribonuclease H superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96AZ6

Ribonuclease H-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96AZ6

Exonuclease, RNase T/DNA polymerase III family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

3'-5'-exoribonuclease activity

determination method

1 reference

9 May 2019

The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

single-stranded DNA 3'-5' exodeoxyribonuclease activity

determination method

1 reference

9 May 2019

The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

exoribonuclease II activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

U3 snoRNA binding

determination method

1 reference

9 May 2019

The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

U2 snRNA binding

determination method

1 reference

9 May 2019

The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

nucleic acid binding

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

U1 snRNA binding

determination method

1 reference

9 May 2019

The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

nuclease activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

hydrolase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

exonuclease activity

determination method

3 references

9 May 2019

Antiviral activities of ISG20 in positive-strand RNA virus infections

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

9 May 2019

Antiviral activities of ISG20 in positive-strand RNA virus infections

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

9 May 2019

The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

determination method

1 reference

9 May 2019

Molecular cloning of a new interferon-induced PML nuclear body-associated protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

determination method

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

9 May 2019

Antiviral activities of ISG20 in positive-strand RNA virus infections

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

biological process

immune system process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

response to virus

determination method

1 reference

9 May 2019

ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

RNA catabolic process

determination method

1 reference

8 April 2019

The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

negative regulation of viral genome replication

determination method

1 reference

8 April 2019

Antiviral activities of ISG20 in positive-strand RNA virus infections

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

DNA catabolic process, exonucleolytic

determination method

1 reference

8 April 2019

The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

type I interferon signaling pathway

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

rRNA processing

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

innate immune response

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

cell population proliferation

determination method

1 reference

1 January 2018

Expression and estrogen regulation of the HEM45 MRNA in human tumor lines and in the rat uterus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

RNA phosphodiester bond hydrolysis, exonucleolytic

determination method

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

defense response to virus

determination method

3 references

9 May 2019

Antiviral activities of ISG20 in positive-strand RNA virus infections

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96AZ6

determination method

Exonuclease, RNase T/DNA polymerase III

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96AZ6

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000306565

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000306565

ENSP00000453638

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000453638

ENSP00000368526

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000368526

ENSP00000453666

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000453666

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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