BCAR1 scaffold protein, Cas family member (Q21115283)

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mammalian protein found in Homo sapiens
  • BCAR1, Cas family scaffolding protein
  • BCAR1
  • BCAR1, Cas family scaffold protein
  • Cas scaffolding protein family member 1
  • breast cancer anti-estrogen resistance protein 1
  • CRK-associated substrate
  • Crk-associated substrate p130Cas
  • p130cas
  • breast cancer anti-estrogen resistance 1
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Language Label Description Also known as
English
BCAR1 scaffold protein, Cas family member
mammalian protein found in Homo sapiens
  • BCAR1, Cas family scaffolding protein
  • BCAR1
  • BCAR1, Cas family scaffold protein
  • Cas scaffolding protein family member 1
  • breast cancer anti-estrogen resistance protein 1
  • CRK-associated substrate
  • Crk-associated substrate p130Cas
  • p130cas
  • breast cancer anti-estrogen resistance 1

Statements

molecular function
protein binding
determination method
IPI
27 references
retrieved
8 April 2019
stated in
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas
GOA
curator
UniProt
UniProt protein ID
P56945
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
CMS: an adapter molecule involved in cytoskeletal rearrangements
GOA
curator
UniProt
UniProt protein ID
P56945
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected].
GOA
curator
UniProt
UniProt protein ID
P56945
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers
GOA
curator
UniProt
UniProt protein ID
P56945
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
p130Cas mediates the transforming properties of the anaplastic lymphoma kinase
GOA
curator
UniProt
UniProt protein ID
P56945
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G
GOA
curator
UniProt
UniProt protein ID
P56945
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Molecular basis for regulation of Src by the docking protein p130Cas
GOA
curator
UniProt
UniProt protein ID
P56945
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition
GOA
curator
UniProt
UniProt protein ID
P56945
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor
GOA
curator
UniProt
UniProt protein ID
P56945
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
P130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected].
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
The role of protein-tyrosine phosphatase 1B in integrin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine phosphorylation of the CrkII adaptor protein modulates cell migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Transformation suppression by protein tyrosine phosphatase 1B requires a functional SH3 ligand
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Cyanidin-3-glucoside inhibits ethanol-induced invasion of breast cancer cells overexpressing ErbB2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Simultaneous assay of Src SH3 and SH2 domain binding using different wavelength fluorescence polarization probes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Sphingosine-1-phosphate induces the association of membrane-type 1 matrix metalloproteinase with p130Cas in endothelial cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Vascular Endothelial Growth Factor (VEGF) Promotes Assembly of the p130Cas Interactome to Drive Endothelial Chemotactic Signaling and Angiogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
protein kinase binding
determination method
IPI
5 references
retrieved
8 April 2019
stated in
Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases
GOA
curator
UniProt
UniProt protein ID
P56945
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells
GOA
curator
UniProt
UniProt protein ID
P56945
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
CAS/Crk coupling serves as a "molecular switch" for induction of cell migration
GOA
curator
UniProt
UniProt protein ID
P56945
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner
GOA
curator
UniProt
UniProt protein ID
P56945
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
retrieved
8 April 2019
stated in
Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins
GOA
curator
UniProt
UniProt protein ID
P56945
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P56945
determination method
IPI
cell component
biological process

Identifiers

Ensembl protein ID
 
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