Tankyrase (Q21115373)

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mammalian protein found in Homo sapiens
  • tankyrase-1
  • tankyrase I
  • ADP-ribosyltransferase diphtheria toxin-like 5
  • TRF1-interacting ankyrin-related ADP-ribose polymerase 1
  • poly [ADP-ribose] polymerase tankyrase-1
  • protein poly-ADP-ribosyltransferase tankyrase-1
  • ARTD5
  • TNKS-1
  • poly [ADP-ribose] polymerase 5A
  • TANK1
  • TRF1-interacting ankyrin-related ADP-ribose polymerase
  • TNKS
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
edit
Language Label Description Also known as
English
Tankyrase
mammalian protein found in Homo sapiens
  • tankyrase-1
  • tankyrase I
  • ADP-ribosyltransferase diphtheria toxin-like 5
  • TRF1-interacting ankyrin-related ADP-ribose polymerase 1
  • poly [ADP-ribose] polymerase tankyrase-1
  • protein poly-ADP-ribosyltransferase tankyrase-1
  • ARTD5
  • TNKS-1
  • poly [ADP-ribose] polymerase 5A
  • TANK1
  • TRF1-interacting ankyrin-related ADP-ribose polymerase
  • TNKS
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase

Statements

molecular function
protein binding
determination method
IPI
19 references
retrieved
8 April 2019
stated in
NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
POT1 as a terminal transducer of TRF1 telomere length control
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
Tankyrase 1 regulates centrosome function by controlling CPAP stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
Tankyrase-1 assembly to large protein complexes blocks its telomeric function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
retrieved
8 April 2019
stated in
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IPI
NAD+ ADP-ribosyltransferase activity
determination method
IDA
TAS
IEA
10 references
retrieved
16 July 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271
determination method
TAS
retrieved
16 July 2018
stated in
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271
determination method
IEA
retrieved
16 July 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271
determination method
IEA
retrieved
16 July 2018
stated in
Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271
determination method
IDA
retrieved
16 July 2018
stated in
NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271
determination method
IDA
retrieved
16 July 2018
stated in
Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271
determination method
IDA
retrieved
16 July 2018
stated in
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271
determination method
IDA
retrieved
16 July 2018
stated in
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271
determination method
IDA
retrieved
16 July 2018
stated in
Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271
determination method
IDA
retrieved
16 July 2018
stated in
The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O95271&geneProductId=UniProtKB:O95271
determination method
IDA
NAD+ ADP-ribosyltransferase activity
determination method
IBA
IDA
IEA
TAS
11 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IEA
retrieved
8 April 2019
stated in
NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IDA
retrieved
8 April 2019
stated in
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IDA
retrieved
8 April 2019
stated in
Tankyrase, a poly(ADP-ribose) polymerase at human telomeres
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IDA
retrieved
8 April 2019
stated in
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IDA
retrieved
8 April 2019
stated in
Poly-ADP ribosylation of Miki by tankyrase-1 promotes centrosome maturation
GOA
curator
UniProt
UniProt protein ID
O95271
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IDA
retrieved
8 April 2019
stated in
Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IDA
retrieved
8 April 2019
stated in
The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182)
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O95271
determination method
IBA
cell component
biological process

Identifiers

PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21115373&oldid=2022961922"