Flotillin 2 (Q21115450)

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mammalian protein found in Homo sapiens

membrane component chromosome 17 surface marker 1
Flotillin 2 (epidermal surface antigen 1)
ESA
flotillin-2
FLOT2
membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)
epidermal surface antigen

Language	Label	Description	Also known as
English	Flotillin 2	mammalian protein found in Homo sapiens	membrane component chromosome 17 surface marker 1 Flotillin 2 (epidermal surface antigen 1) ESA flotillin-2 FLOT2 membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1) epidermal surface antigen

Statements

1 reference

13 November 2019

UniProt protein ID

Band 7/SPFH domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14254

Flotillin family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14254

Flotillin, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Band 7 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protease binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

protein binding

determination method

7 references

8 April 2019

The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

Role of dynamin and clathrin in the cellular trafficking of flotillins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

Arginase-flotillin interaction brings arginase to red blood cell membrane

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

Unconventional secretion of synuclein-γ promotes tumor cell invasion

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

Analysis of close associations of uropod-associated proteins in human T-cells using the proximity ligation assay

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

ionotropic glutamate receptor binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

determination method

1 reference

8 April 2019

The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

determination method

3 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14254&geneProductId=UniProtKB:Q14254

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14254&geneProductId=UniProtKB:Q14254

determination method

26 September 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14254&geneProductId=UniProtKB:Q14254

determination method

cell-cell contact zone

determination method

1 reference

8 April 2019

Flotillin-2 expression in the human gut: from a cell model to human tissue in health and inflammatory bowel diseases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

determination method

1 reference

26 September 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14254&geneProductId=UniProtKB:Q14254

determination method

endocytic vesicle

determination method

1 reference

8 April 2019

A Protein Interaction Network for Ecm29 Links the 26 S Proteasome to Molecular Motors and Endosomal Components

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

acrosomal membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

flotillin complex

determination method

4 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

Flotillin microdomains stabilize cadherins at cell-cell junctions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

determination method

1 reference

8 April 2019

Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

basolateral plasma membrane

determination method

1 reference

8 April 2019

Flotillin-2 expression in the human gut: from a cell model to human tissue in health and inflammatory bowel diseases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

apical plasma membrane

determination method

1 reference

8 April 2019

Flotillin-2 expression in the human gut: from a cell model to human tissue in health and inflammatory bowel diseases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

cortical actin cytoskeleton

determination method

1 reference

8 April 2019

Flotillin microdomains stabilize cadherins at cell-cell junctions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

perinuclear region of cytoplasm

determination method

1 reference

8 April 2019

The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

extracellular exosome

determination method

4 references

26 September 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14254&geneProductId=UniProtKB:Q14254

determination method

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14254&geneProductId=UniProtKB:Q14254

determination method

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14254&geneProductId=UniProtKB:Q14254

determination method

26 September 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14254&geneProductId=UniProtKB:Q14254

determination method

cytoplasmic vesicle

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

Flotillin-2 expression in the human gut: from a cell model to human tissue in health and inflammatory bowel diseases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

Differences in the expression and distribution of flotillin-2 in chick, mice and human muscle cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

determination method

1 reference

8 April 2019

Flotillin microdomains stabilize cadherins at cell-cell junctions

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

plasma membrane

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

The human gene for an epidermal surface antigen (M17S1) is located at 17q11–12

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

determination method

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

determination method

dendrite cytoplasm

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

extracellular exosome

determination method

3 references

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

glutamatergic synapse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

anchored component of presynaptic active zone membrane

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

biological process

positive regulation of establishment of T cell polarity

determination method

1 reference

8 April 2019

Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

regulation of toll-like receptor 3 signaling pathway

determination method

1 reference

8 April 2019

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

regulation of heterotypic cell-cell adhesion

determination method

1 reference

8 April 2019

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

protein stabilization

determination method

1 reference

8 April 2019

Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

negative regulation of amyloid precursor protein catabolic process

determination method

1 reference

8 April 2019

Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

negative regulation of gene expression

determination method

1 reference

8 April 2019

Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

protein localization to plasma membrane raft

determination method

1 reference

8 April 2019

Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

membrane raft assembly

determination method

1 reference

8 April 2019

Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

epidermis development

determination method

1 reference

8 April 2019

Cloning and characterization of a novel epidermal cell surface antigen (ESA)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

protein localization to plasma membrane

determination method

1 reference

8 April 2019

Flotillins bind to the dileucine sorting motif of β-site amyloid precursor protein-cleaving enzyme 1 and influence its endosomal sorting

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

anterograde dendritic transport

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

regulation of postsynaptic membrane neurotransmitter receptor levels

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

positive regulation of NF-kappaB transcription factor activity

determination method

1 reference

8 April 2019

Downregulation of miR-138 sustains NF-κB activation and promotes lipid raft formation in esophageal squamous cell carcinoma.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14254

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14254

Flotillin, C-terminal domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q14254

Commons category

Flotillin-2

0 references

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000378368

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378368

ENSP00000378366

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378366

ENSP00000463304

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463304

ENSP00000463503

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000463503

ENSP00000465022

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465022

ENSP00000465819

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465819

PDB structure ID

1 reference

10 November 2015

http://www.uniprot.org/uniprot/Q60634.txt?version=134

Sitelinks

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Wikisource(0 entries)

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Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(1 entry)

commonswiki Category:Flotillin-2

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