Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 (Q21116529)

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mammalian protein found in Homo sapiens

PREX1
PIP3 dependent Rac exchange factor 1
phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
ptdIns(3,4,5)-dependent Rac exchanger 1

Language	Label	Description	Also known as
English	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	mammalian protein found in Homo sapiens	PREX1 PIP3 dependent Rac exchange factor 1 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein ptdIns(3,4,5)-dependent Rac exchanger 1

Statements

1 reference

13 November 2019

UniProt protein ID

winged helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

Winged helix-like DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

Dbl homology (DH) domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

PDZ superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PDZ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DEP domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Dbl homology (DH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Guanine-nucleotide dissociation stimulator, CDC24, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

GTPase activator activity

determination method

1 reference

8 April 2019

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

protein binding

determination method

3 references

8 April 2019

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

8 April 2019

Selective activation of Akt1 by mammalian target of rapamycin complex 2 regulates cancer cell migration, invasion, and metastasis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

8 April 2019

Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

determination method

1 reference

8 April 2019

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

phospholipid binding

determination method

1 reference

8 April 2019

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

guanyl-nucleotide exchange factor activity

determination method

3 references

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

plasma membrane

determination method

3 references

5 June 2018

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCU6&geneProductId=UniProtKB:Q8TCU6

determination method

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCU6&geneProductId=UniProtKB:Q8TCU6

determination method

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCU6&geneProductId=UniProtKB:Q8TCU6

determination method

dendritic shaft

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

perinuclear region of cytoplasm

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

8 April 2019

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

plasma membrane

determination method

4 references

8 April 2019

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

biological process

intracellular signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

neutrophil activation

determination method

1 reference

8 April 2019

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

regulation of dendrite development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

neutrophil chemotaxis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

reactive oxygen species metabolic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

regulation of actin filament polymerization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

actin filament polymerization

determination method

1 reference

8 April 2019

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

positive regulation of GTPase activity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

positive regulation of substrate adhesion-dependent cell spreading

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

T cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

regulation of Rho protein signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

superoxide metabolic process

determination method

1 reference

8 April 2019

Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma?

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

positive regulation of cell adhesion

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

negative regulation of protein kinase activity

determination method

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCU6&geneProductId=UniProtKB:Q8TCU6

determination method

positive regulation of cell migration

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

negative regulation of TOR signaling

determination method

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCU6&geneProductId=UniProtKB:Q8TCU6

determination method

positive regulation of apoptotic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

regulation of small GTPase mediated signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCU6

determination method

G protein-coupled receptor signaling pathway

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

Dbl homology (DH) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

pleckstrin homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

Guanine-nucleotide dissociation stimulator, CDC24, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TCU6

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000361009

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000361009

ENSP00000434632

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000434632

ENSP00000481444

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000481444

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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