DNA topoisomerase II binding protein 1 (Q21116531)

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mammalian protein found in Homo sapiens

DNA topoisomerase 2-binding protein 1
DNA topoisomerase II-beta-binding protein 1
topoisomerase (DNA) II binding protein 1
DNA topoisomerase II-binding protein 1
TOPBP1

Language	Label	Description	Also known as
English	DNA topoisomerase II binding protein 1	mammalian protein found in Homo sapiens	DNA topoisomerase 2-binding protein 1 DNA topoisomerase II-beta-binding protein 1 topoisomerase (DNA) II binding protein 1 DNA topoisomerase II-binding protein 1 TOPBP1

Statements

1 reference

13 November 2019

UniProt protein ID

Secretoglobin superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92547

BRCT domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92547

BRCT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

protein C-terminus binding

determination method

1 reference

8 April 2019

A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

protein binding

determination method

7 references

8 April 2019

A vertebrate gene, ticrr, is an essential checkpoint and replication regulator

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

8 April 2019

A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

8 April 2019

PML colocalizes with and stabilizes the DNA damage response protein TopBP1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

8 April 2019

Characterization of the interaction between the human DNA topoisomerase IIbeta-binding protein 1 (TopBP1) and the cell division cycle 45 (Cdc45) protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

8 April 2019

The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

8 April 2019

Regulation of TopBP1 oligomerization by Akt/PKB for cell survival

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

8 April 2019

Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

identical protein binding

determination method

1 reference

8 April 2019

Regulation of TopBP1 oligomerization by Akt/PKB for cell survival

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

determination method

1 reference

8 April 2019

PML colocalizes with and stabilizes the DNA damage response protein TopBP1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

male germ cell nucleus

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

microtubule organizing center

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

8 April 2019

A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

condensed nuclear chromosome

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

actin cytoskeleton

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

determination method

3 references

8 April 2019

A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

biological process

response to ionizing radiation

determination method

1 reference

8 April 2019

PML colocalizes with and stabilizes the DNA damage response protein TopBP1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

DNA metabolic process

determination method

1 reference

8 April 2019

A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

DNA replication initiation

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92547&geneProductId=UniProtKB:Q92547

determination method

mitotic G2 DNA damage checkpoint signaling

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92547&geneProductId=UniProtKB:Q92547

determination method

mitotic DNA replication checkpoint signaling

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

DNA replication

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

regulation of signal transduction by p53 class mediator

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92547

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92547

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000260810

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000260810

ENSP00000458790

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000458790

ENSP00000493612

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000493612

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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