Aph-1 homolog A, gamma-secretase subunit (Q21116606)

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mammalian protein found in Homo sapiens

aph-1alpha
APH1A
APH1A gamma secretase subunit
presenilin-stabilization factor
anterior pharynx defective 1 homolog A
gamma-secretase subunit APH-1A

Language	Label	Description	Also known as
English	Aph-1 homolog A, gamma-secretase subunit	mammalian protein found in Homo sapiens	aph-1alpha APH1A APH1A gamma secretase subunit presenilin-stabilization factor anterior pharynx defective 1 homolog A gamma-secretase subunit APH-1A

Statements

1 reference

13 November 2019

UniProt protein ID

Gamma-secretase subunit Aph-1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q96BI3

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method or standard

5 references

8 April 2019

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

Cellular localization of Nicastrin affects amyloid beta species production

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

An atomic structure of human γ-secretase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

endoplasmic reticulum membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

plasma membrane

determination method or standard

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BI3&geneProductId=UniProtKB:Q96BI3

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

17 October 2017

Purification and characterization of the human gamma-secretase complex

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BI3&geneProductId=UniProtKB:Q96BI3

determination method or standard

Golgi cisterna membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

integral component of membrane

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

Three-dimensional structure of human γ-secretase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

An atomic structure of human γ-secretase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

endoplasmic reticulum

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

Purification and characterization of the human gamma-secretase complex

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

synaptic vesicle

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

endosome membrane

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

gamma-secretase complex

determination method or standard

3 references

8 April 2019

Three-dimensional structure of human γ-secretase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

An atomic structure of human γ-secretase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

synaptic membrane

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

integral component of presynaptic membrane

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

biological process

ephrin receptor signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

membrane protein ectodomain proteolysis

determination method or standard

1 reference

8 April 2019

Purification and characterization of the human gamma-secretase complex

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

positive regulation of apoptotic process

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

Notch receptor processing

determination method or standard

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BI3&geneProductId=UniProtKB:Q96BI3

determination method or standard

17 October 2017

Purification and characterization of the human gamma-secretase complex

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BI3&geneProductId=UniProtKB:Q96BI3

determination method or standard

17 October 2017

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BI3&geneProductId=UniProtKB:Q96BI3

determination method or standard

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BI3&geneProductId=UniProtKB:Q96BI3

determination method or standard

metanephros development

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

amyloid precursor protein catabolic process

determination method or standard

Notch signaling pathway

determination method or standard

Notch receptor processing

determination method or standard

4 references

8 April 2019

Purification and characterization of the human gamma-secretase complex

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

protein processing

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

Purification and characterization of the human gamma-secretase complex

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

membrane protein intracellular domain proteolysis

determination method or standard

1 reference

1 January 2018

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q96BI3&geneProductId=UniProtKB:Q96BI3

determination method or standard

Notch receptor processing, ligand-dependent

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q96BI3

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000353380

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353380

ENSP00000358105

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000358105

ENSP00000397473

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000397473

ENSP00000236017

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000236017

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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