PAF1 homolog, Paf1/RNA polymerase II complex component (Q21117097)

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mammalian protein found in Homo sapiens

PAF1
Paf1, RNA polymerase II associated factor, homolog
RNA polymerase II-associated factor 1 homolog
pancreatic differentiation protein 2

Language	Label	Description	Also known as
English	PAF1 homolog, Paf1/RNA polymerase II complex component	mammalian protein found in Homo sapiens	PAF1 Paf1, RNA polymerase II associated factor, homolog RNA polymerase II-associated factor 1 homolog pancreatic differentiation protein 2

Statements

1 reference

13 November 2019

UniProt protein ID

RNA polymerase II associated factor Paf1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N7H5

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

RNA polymerase II complex binding

determination method

1 reference

24 April 2018

The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N7H5&geneProductId=UniProtKB:Q8N7H5

determination method

chromatin binding

determination method

1 reference

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N7H5&geneProductId=UniProtKB:Q8N7H5

determination method

protein binding

determination method

13 references

8 April 2019

The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

Next-generation sequencing to generate interactome datasets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

Suppression of the antiviral response by an influenza histone mimic

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

The human PAF complex coordinates transcription with events downstream of RNA synthesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

determination method

1 reference

8 April 2019

Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

determination method

1 reference

8 April 2019

Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

Cdc73/Paf1 complex

determination method

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N7H5&geneProductId=UniProtKB:Q8N7H5

determination method

24 April 2018

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N7H5&geneProductId=UniProtKB:Q8N7H5

determination method

24 April 2018

The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N7H5&geneProductId=UniProtKB:Q8N7H5

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

Cdc73/Paf1 complex

determination method

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

biological process

histone monoubiquitination

determination method

1 reference

8 April 2019

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

regulation of transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N7H5&geneProductId=UniProtKB:Q8N7H5

determination method

positive regulation of histone methylation

determination method

1 reference

8 April 2019

Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

positive regulation of mRNA 3'-end processing

determination method

1 reference

8 April 2019

Transcriptional activators enhance polyadenylation of mRNA precursors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

histone modification

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

Wnt signaling pathway

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N7H5&geneProductId=UniProtKB:Q8N7H5

determination method

stem cell population maintenance

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

mRNA polyadenylation

determination method

1 reference

8 April 2019

Transcriptional activators enhance polyadenylation of mRNA precursors

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

protein localization to nucleus

determination method

1 reference

8 April 2019

Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

histone H2B ubiquitination

determination method

1 reference

8 April 2019

Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

negative regulation of myeloid cell differentiation

determination method

1 reference

8 April 2019

The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

positive regulation of transcription elongation from RNA polymerase II promoter

determination method

1 reference

8 April 2019

The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

transcription by RNA polymerase II

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

protein ubiquitination

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

positive regulation of cell cycle G1/S phase transition

determination method

1 reference

8 April 2019

The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N7H5

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000221265

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000221265

ENSP00000468874

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468874

ENSP00000396412

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000396412

ENSP00000469742

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000469742

PDB structure ID

1 reference

UniProt protein ID

21 March 2016

language of work or name

Sitelinks

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