Chitinase 3 like 1 (Q21117210)

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mammalian protein found in Homo sapiens

YKL-40
hCGP-39
CGP-39
cartilage glycoprotein 39
CHI3L1
chitinase-3-like protein 1
39 kDa synovial protein
chitinase 3-like 1 (cartilage glycoprotein-39)
GP-39

Language	Label	Description	Also known as
English	Chitinase 3 like 1	mammalian protein found in Homo sapiens	YKL-40 hCGP-39 CGP-39 cartilage glycoprotein 39 CHI3L1 chitinase-3-like protein 1 39 kDa synovial protein chitinase 3-like 1 (cartilage glycoprotein-39) GP-39

Statements

1 reference

13 November 2019

UniProt protein ID

0 references

Chitinase insertion domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36222

glycoside hydrolase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36222

chitinase-3-like protein 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36222

Chitinase II domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Glycoside hydrolase family 18, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

chitinase activity

determination method

2 references

8 April 2019

Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

8 April 2019

Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

extracellular matrix structural constituent

determination method

1 reference

8 April 2019

Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

determination method

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36222&geneProductId=UniProtKB:P36222

determination method

26 September 2017

Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36222&geneProductId=UniProtKB:P36222

determination method

26 September 2017

Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36222&geneProductId=UniProtKB:P36222

determination method

carbohydrate binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

protein binding

determination method

3 references

8 April 2019

Galectin-3 Interacts with the CHI3L1 Axis and Contributes to Hermansky-Pudlak Syndrome Lung Disease.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

8 April 2019

IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

8 April 2019

Tumor-recruited M2 macrophages promote gastric and breast cancer metastasis via M2 macrophage-secreted CHI3L1 protein

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

8 April 2019

Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

8 April 2019

Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

endoplasmic reticulum

determination method

perinuclear region of cytoplasm

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

extracellular exosome

determination method

extracellular region

determination method

2 references

extracellular space

determination method

6 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36222&geneProductId=UniProtKB:P36222

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36222&geneProductId=UniProtKB:P36222

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36222&geneProductId=UniProtKB:P36222

determination method

26 September 2017

Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36222&geneProductId=UniProtKB:P36222

determination method

26 September 2017

Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36222&geneProductId=UniProtKB:P36222

determination method

26 September 2017

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36222&geneProductId=UniProtKB:P36222

determination method

specific granule lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

determination method

4 references

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36222&geneProductId=UniProtKB:P36222

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36222&geneProductId=UniProtKB:P36222

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36222&geneProductId=UniProtKB:P36222

determination method

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36222&geneProductId=UniProtKB:P36222

determination method

extracellular region

determination method

extracellular space

determination method

6 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

8 April 2019

Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

8 April 2019

Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

8 April 2019

Human colostrum: identification of minor proteins in the aqueous phase by proteomics

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

determination method

extracellular matrix

determination method

1 reference

8 April 2019

Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

extracellular exosome

determination method

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

biological process

response to interleukin-1

determination method

1 reference

8 April 2019

Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

response to interleukin-6

determination method

1 reference

8 April 2019

IL-6, but not TNF-α, increases plasma YKL-40 in human subjects

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

lung development

determination method

1 reference

8 April 2019

Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

response to mechanical stimulus

determination method

1 reference

8 April 2019

The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

response to tumor necrosis factor

determination method

1 reference

8 April 2019

Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

cartilage development

determination method

1 reference

8 April 2019

Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

cellular response to interleukin-1

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

1 reference

8 April 2019

Role of YKL-40 in the angiogenesis, radioresistance, and progression of glioblastoma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

inflammatory response

determination method

3 references

8 April 2019

Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

apoptotic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

neutrophil degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

chitin catabolic process

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P36222&geneProductId=UniProtKB:P36222

determination method

carbohydrate metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P36222

determination method

Glycoside hydrolase family 18, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36222

Chitinase II domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P36222

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000385350

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000385350

ENSP00000255409

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000255409

PDB structure ID

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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