Cytosolic iron-sulfur assembly component 1 (Q21117221)

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mammalian protein found in Homo sapiens

probable cytosolic iron-sulfur protein assembly protein CIAO1
CIAO1
WD repeat-containing protein 39
WD repeat domain 39
WD40 protein Ciao1
cytosolic iron-sulfur protein assembly 1 homolog

Language	Label	Description	Also known as
English	Cytosolic iron-sulfur assembly component 1	mammalian protein found in Homo sapiens	probable cytosolic iron-sulfur protein assembly protein CIAO1 CIAO1 WD repeat-containing protein 39 WD repeat domain 39 WD40 protein Ciao1 cytosolic iron-sulfur protein assembly 1 homolog

Statements

1 reference

13 November 2019

UniProt protein ID

WD40/YVTN repeat-like-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O76071

WD40-repeat-containing domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O76071

Probable cytosolic iron-sulfur protein assembly protein, CIAO1/Cia1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O76071

WD40 repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

WD40 repeat, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

7 references

8 April 2019

IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

The CIA Targeting Complex Is Highly Regulated and Provides Two Distinct Binding Sites for Client Iron-Sulfur Proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

Next-generation sequencing to generate interactome datasets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

determination method

5 references

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76071&geneProductId=UniProtKB:O76071

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76071&geneProductId=UniProtKB:O76071

determination method

16 July 2018

MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76071&geneProductId=UniProtKB:O76071

determination method

16 July 2018

MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76071&geneProductId=UniProtKB:O76071

determination method

16 July 2018

Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76071&geneProductId=UniProtKB:O76071

determination method

determination method

1 reference

27 March 2018

MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76071&geneProductId=UniProtKB:O76071

determination method

determination method

1 reference

10 September 2018

IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76071&geneProductId=UniProtKB:O76071

determination method

determination method

7 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

biological process

regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

positive regulation of cell population proliferation

determination method

1 reference

8 April 2019

Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

chromosome segregation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

iron-sulfur cluster assembly

determination method

4 references

16 July 2018

Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76071&geneProductId=UniProtKB:O76071

determination method

16 July 2018

Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76071&geneProductId=UniProtKB:O76071

determination method

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76071&geneProductId=UniProtKB:O76071

determination method

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O76071&geneProductId=UniProtKB:O76071

determination method

protein maturation by iron-sulfur cluster transfer

determination method

1 reference

8 April 2019

Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

iron-sulfur cluster assembly

determination method

5 references

8 April 2019

Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

Structure of the yeast WD40 domain protein Cia1, a component acting late in iron-sulfur protein biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76071

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O76071

WD40 repeat, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O76071

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000418287

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000418287

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wiktionary(0 entries)

Multilingual sites(0 entries)

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