NADH dehydrogenase, subunit 1 (complex I) (Q21117538)

http://www.ebi.ac.uk/interpro/protein/P03886

NADH:ubiquinone oxidoreductase, subunit 1, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

oxidoreductase activity

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03886&geneProductId=UniProtKB:P03886

3 references

8 April 2019

DJ-1 binds to mitochondrial complex I and maintains its activity

GOA

curator

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

8 April 2019

Interactions between PBEF and oxidative stress proteins--a potential new mechanism underlying PBEF in the pathogenesis of acute lung injury

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

8 April 2019

Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells

GOA

curator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

NADH dehydrogenase activity

IPI

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

NADH dehydrogenase (ubiquinone) activity

1 reference

8 April 2019

Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

integral component of membrane

NAS

cell component

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

mitochondrial respiratory chain complex I

3 references

10 September 2018

Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03886&geneProductId=UniProtKB:P03886

10 September 2018

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03886&geneProductId=UniProtKB:P03886

10 September 2018

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03886&geneProductId=UniProtKB:P03886

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits

mitochondrial membranes

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

2 references

mitochondrial respiratory chain complex I

4 references

8 April 2019

Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

8 April 2019

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

8 April 2019

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

response to hydroperoxide

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

response to organic cyclic compound

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

mitochondrial respiratory chain complex I assembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03886&geneProductId=UniProtKB:P03886

mitochondrial electron transport, NADH to ubiquinone

1 reference

1 January 2018

Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P03886&geneProductId=UniProtKB:P03886

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P03886

physically interacts with

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1431

metformin hydrochloride

object has role

reaction inhibitor

1 reference

stated in

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1703

has part(s)

NADH:ubiquinone oxidoreductase, subunit 1, conserved site

1 reference

stated in

InterPro Release 71.0