SET domain containing 2, histone lysine methyltransferase (Q21118252)

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mammalian protein found in Homo sapiens

hSET2
SETD2
HIP-1
p231HBP
huntingtin yeast partner B
lysine N-methyltransferase 3A
protein-lysine N-methyltransferase SETD2
Huntingtin-interacting protein 1
SET domain containing 2
histone-lysine N-methyltransferase SETD2
huntingtin-interacting protein B
huntingtin interacting protein 1
HIF-1
SET domain-containing protein 2
SETD2 protein, human

Language	Label	Description	Also known as
English	SET domain containing 2, histone lysine methyltransferase	mammalian protein found in Homo sapiens	hSET2 SETD2 HIP-1 p231HBP huntingtin yeast partner B lysine N-methyltransferase 3A protein-lysine N-methyltransferase SETD2 Huntingtin-interacting protein 1 SET domain containing 2 histone-lysine N-methyltransferase SETD2 huntingtin-interacting protein B huntingtin interacting protein 1 HIF-1 SET domain-containing protein 2 SETD2 protein, human

Statements

1 reference

13 November 2019

UniProt protein ID

WW domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9BYW2

TFIIS/LEDGF domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9BYW2

Set2 Rpb1 interacting domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9BYW2

Post-SET domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Set2 Rpb1 interacting domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SET domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

WW domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

AWS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

methyltransferase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

transferase activity

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

protein binding

determination method

4 references

9 May 2019

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

Huntingtin interacting proteins are genetic modifiers of neurodegeneration

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

histone-lysine N-methyltransferase activity

determination method

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

protein-lysine N-methyltransferase activity

determination method

1 reference

9 May 2019

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

alpha-tubulin binding

determination method

1 reference

9 May 2019

Dual Chromatin and Cytoskeletal Remodeling by SETD2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

histone methyltransferase activity (H3-K36 specific)

determination method

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

metal ion binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

determination method

4 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

biological process

regulation of transcription, DNA-templated

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

histone H3-K36 dimethylation

determination method

1 reference

9 May 2019

Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

regulation of mRNA export from nucleus

determination method

1 reference

9 May 2019

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

embryonic organ development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

stem cell development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

embryonic placenta morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

transcription elongation from RNA polymerase II promoter

determination method

1 reference

9 May 2019

Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

coronary vasculature morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

cell migration involved in vasculogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

morphogenesis of a branching structure

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9BYW2&geneProductId=UniProtKB:Q9BYW2

determination method

mesoderm morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

histone H3-K36 methylation

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

neural tube closure

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

nucleosome organization

determination method

1 reference

9 May 2019

Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

pericardium development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

regulation of gene expression

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

histone H3-K36 trimethylation

determination method

10 references

9 May 2019

Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

9 May 2019

Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

embryonic cranial skeleton morphogenesis

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

DNA mismatch repair

determination method

1 reference

9 May 2019

The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

histone lysine methylation

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

forebrain development

determination method

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

regulation of double-strand break repair via homologous recombination

determination method

1 reference

9 May 2019

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

peptidyl-lysine monomethylation

determination method

1 reference

9 May 2019

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

regulation of cytokinesis

determination method

1 reference

9 May 2019

Dual Chromatin and Cytoskeletal Remodeling by SETD2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

positive regulation of interferon-alpha production

determination method

1 reference

9 May 2019

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

response to type I interferon

determination method

1 reference

9 May 2019

Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

microtubule cytoskeleton organization involved in mitosis

determination method

1 reference

9 May 2019

Dual Chromatin and Cytoskeletal Remodeling by SETD2.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

regulation of protein localization to chromatin

determination method

1 reference

9 May 2019

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

immune system process

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

cellular response to DNA damage stimulus

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

multicellular organism development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

cell differentiation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

innate immune response

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

chromatin organization

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9BYW2

determination method

Identifiers

MeSH descriptor ID

subject named as

SETD2 protein, human

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000386759

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000386759

ENSP00000332415

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000332415

ENSP00000388349

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000388349

ENSP00000411901

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411901

ENSP00000416401

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000416401

ENSP00000491413

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000491413

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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