Protein phosphatase 3 catalytic subunit beta (Q21118452)

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mammalian protein found in Homo sapiens

serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
protein phosphatase from PCR fragment H32
calmodulin-dependent calcineurin A subunit beta isoform
PPP3CB
CNA beta
calcineurin A beta
protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform
calcineurin A2
CAM-PRP catalytic subunit
protein phosphatase 3, catalytic subunit, beta isozyme
protein phosphatase 2B, catalytic subunit, beta isoform

Language	Label	Description	Also known as
English	Protein phosphatase 3 catalytic subunit beta	mammalian protein found in Homo sapiens	serine/threonine-protein phosphatase 2B catalytic subunit beta isoform protein phosphatase from PCR fragment H32 calmodulin-dependent calcineurin A subunit beta isoform PPP3CB CNA beta calcineurin A beta protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform calcineurin A2 CAM-PRP catalytic subunit protein phosphatase 3, catalytic subunit, beta isozyme protein phosphatase 2B, catalytic subunit, beta isoform

Statements

1 reference

13 November 2019

UniProt protein ID

Metallo-dependent phosphatase-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16298

Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase family

1 reference

based on heuristic

inferred from protein domain or family

Calcineurin-like phosphoesterase

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

calcium ion binding

determination method

1 reference

8 April 2019

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

phosphoprotein phosphatase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

protein dimerization activity

determination method

1 reference

8 April 2019

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

calmodulin binding

determination method

5 references

16 July 2018

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method

16 July 2018

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method

16 July 2018

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method

16 July 2018

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method

protein binding

determination method

3 references

8 April 2019

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

determination method

1 reference

8 April 2019

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

protein phosphatase 2B binding

determination method

1 reference

8 April 2019

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

calmodulin-dependent protein phosphatase activity

determination method

5 references

16 July 2018

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method

16 July 2018

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method

16 July 2018

The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method

calmodulin binding

determination method

6 references

8 April 2019

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

calmodulin-dependent protein phosphatase activity

determination method

6 references

8 April 2019

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

calcineurin complex

determination method

3 references

16 July 2018

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method

16 July 2018

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method

16 July 2018

Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P16298&geneProductId=UniProtKB:P16298

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

glutamatergic synapse

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

calcineurin complex

determination method

4 references

8 April 2019

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

biological process

response to cytokine

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

lymphangiogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

regulation of insulin secretion

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

calcineurin-NFAT signaling cascade

determination method

determination method

1 reference

8 April 2019

ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

determination method

1 reference

8 April 2019

ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

regulation of synaptic plasticity

determination method

1 reference

8 April 2019

ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

T cell homeostasis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

positive regulation of transcription, DNA-templated

determination method

1 reference

8 April 2019

Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

negative regulation of T cell mediated cytotoxicity

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

T cell proliferation

determination method

1 reference

8 April 2019

Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

Fc-epsilon receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

heart development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

T cell differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

determination method

1 reference

8 April 2019

ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

regulation of gene expression

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

social behavior

determination method

1 reference

1 January 2018

ANXA7, PPP3CB, DNAJC9, and ZMYND17 genes at chromosome 10q22 associated with the subgroup of schizophrenia with deficits in attention and executive function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

locomotion involved in locomotory behavior

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

T cell activation

determination method

1 reference

8 April 2019

Genetic conservation of the immunophilin-binding domains of human calcineurin A1 and A2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

8 April 2019

Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

signal transduction

determination method

1 reference

8 April 2019

Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

dephosphorylation

determination method

1 reference

8 April 2019

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

Wnt signaling pathway, calcium modulating pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

protein dephosphorylation

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

The proline-rich N-terminal sequence of calcineurin Abeta determines substrate binding

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

8 April 2019

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

regulation of synaptic vesicle endocytosis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

calcineurin-mediated signaling

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P16298

determination method

Calcineurin-like phosphoesterase domain, ApaH type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16298

Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P16298

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000353881

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353881

ENSP00000378305

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378305

ENSP00000378306

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378306

ENSP00000343147

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000343147

ENSP00000398022

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000398022

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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