MutS homolog 3 (Q21118766)

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mammalian protein found in Homo sapiens

mismatch repair protein 1
DUP
MSH3
MRP1
divergent upstream protein
hMSH3
epididymis secretory sperm binding protein
DNA mismatch repair protein Msh3
MutS Homolog 3 Protein

Language	Label	Description	Also known as
English	MutS homolog 3	mammalian protein found in Homo sapiens	mismatch repair protein 1 DUP MSH3 MRP1 divergent upstream protein hMSH3 epididymis secretory sperm binding protein DNA mismatch repair protein Msh3 MutS Homolog 3 Protein

Statements

1 reference

16 January 2019

UniProt protein ID

MutS, connector domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20585

DNA mismatch repair protein MutS/MSH

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20585

DNA mismatch repair protein MutS, core domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20585

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20585

DNA mismatch repair protein MutS, N-terminal domain, protein family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P20585

DNA mismatch repair protein MutS, connector domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA mismatch repair protein MutS, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA mismatch repair protein MutS, core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DNA mismatch repair protein MutS-like, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

16 January 2019

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

molecular function

nucleotide binding

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

protein homodimerization activity

determination method

1 reference

9 May 2019

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

dinucleotide insertion or deletion binding

determination method

1 reference

9 May 2019

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

oxidized purine DNA binding

determination method

1 reference

9 May 2019

Activation of human MutS homologs by 8-oxo-guanine DNA damage

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

single-stranded DNA binding

determination method

1 reference

9 May 2019

hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

protein binding

determination method

8 references

9 May 2019

Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

9 May 2019

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

9 May 2019

(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

9 May 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

9 May 2019

Interactions of human hMSH2 with hMSH3 and hMSH2 with hMSH6: examination of mutations found in hereditary nonpolyposis colorectal cancer

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

9 May 2019

Mechanism of mismatch recognition revealed by human MutSβ bound to unpaired DNA loops

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

9 May 2019

The nucleotide binding dynamics of human MSH2-MSH3 are lesion dependent

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

9 May 2019

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

dinucleotide repeat insertion binding

determination method

1 reference

9 May 2019

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

single guanine insertion binding

determination method

1 reference

9 May 2019

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

guanine/thymine mispair binding

determination method

1 reference

9 May 2019

hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

Y-form DNA binding

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20585&geneProductId=UniProtKB:P20585

determination method

heteroduplex DNA loop binding

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20585&geneProductId=UniProtKB:P20585

determination method

double-strand/single-strand DNA junction binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

damaged DNA binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

ATP-dependent activity, acting on DNA

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

determination method

single thymine insertion binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

mismatched DNA binding

determination method

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

9 May 2019

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

DNA insertion or deletion binding

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

MutSbeta complex

determination method

1 reference

17 October 2017

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20585&geneProductId=UniProtKB:P20585

determination method

determination method

1 reference

17 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20585&geneProductId=UniProtKB:P20585

determination method

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

determination method

1 reference

9 May 2019

MCM9 Is Required for Mammalian DNA Mismatch Repair.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

determination method

1 reference

9 May 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

mismatch repair complex

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

biological process

cellular response to DNA damage stimulus

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

maintenance of DNA repeat elements

determination method

1 reference

17 October 2017

Transcription promotes contraction of CAG repeat tracts in human cells

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20585&geneProductId=UniProtKB:P20585

determination method

positive regulation of helicase activity

determination method

1 reference

17 October 2017

Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20585&geneProductId=UniProtKB:P20585

determination method

negative regulation of DNA recombination

determination method

1 reference

9 May 2019

Physical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factors

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

DNA mismatch repair

determination method

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20585&geneProductId=UniProtKB:P20585

determination method

17 October 2017

Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20585&geneProductId=UniProtKB:P20585

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P20585&geneProductId=UniProtKB:P20585

determination method

somatic recombination of immunoglobulin gene segments

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

meiotic mismatch repair

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

removal of nonhomologous ends

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

DNA mismatch repair

determination method

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

9 May 2019

Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

mitotic recombination

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

reciprocal meiotic recombination

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

replication fork arrest

determination method

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P20585

determination method

Identifiers

MeSH descriptor ID

subject named as

MutS Homolog 3 Protein

0 references

D12.776.260.556.875

0 references

RefSeq protein ID

1 reference

8 February 2019

UniProt protein ID

1 reference

16 January 2019

UniProt protein ID

Ensembl protein ID

ENSP00000265081

1 reference

ensembl Release 96

Ensembl protein ID

ENSP00000265081

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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