Sterol regulatory element binding transcription factor 2 (Q21119108)

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mammalian protein found in Homo sapiens

sterol regulatory element-binding protein 2
class D basic helix-loop-helix protein 2
Sterol regulatory element-binding transcription factor 2
bHLHd2
SREBF2

Language	Label	Description	Also known as
English	Sterol regulatory element binding transcription factor 2	mammalian protein found in Homo sapiens	sterol regulatory element-binding protein 2 class D basic helix-loop-helix protein 2 Sterol regulatory element-binding transcription factor 2 bHLHd2 SREBF2

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

C-8 sterol isomerase activity

determination method

1 reference

27 February 2018

Identification and pharmacological characterization of SRBP-2: a novel SR31747A-binding protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

protein dimerization activity

determination method

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

DNA-binding transcription factor activity

determination method

1 reference

27 February 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

DNA-binding transcription repressor activity, RNA polymerase II-specific

determination method

1 reference

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

determination method

1 reference

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

protein C-terminus binding

determination method

1 reference

27 February 2018

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

protein binding

determination method

7 references

27 February 2018

The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

A human MAP kinase interactome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

DNA-binding transcription factor activity, RNA polymerase II-specific

determination method

determination method

3 references

27 February 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Identification and pharmacological characterization of SRBP-2: a novel SR31747A-binding protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

integral component of membrane

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

determination method

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

SREBP-SCAP-Insig complex

determination method

2 references

27 February 2018

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

Golgi apparatus

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

determination method

2 references

endoplasmic reticulum

determination method

3 references

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Identification and pharmacological characterization of SRBP-2: a novel SR31747A-binding protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

ER to Golgi transport vesicle membrane

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

cytoplasmic vesicle

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

determination method

7 references

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Identification and pharmacological characterization of SRBP-2: a novel SR31747A-binding protein

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

determination method

2 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

determination method

1 reference

27 February 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

intracellular membrane-bounded organelle

determination method

1 reference

27 February 2018

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

biological process

steroid metabolic process

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

positive regulation of protein targeting to mitochondrion

determination method

1 reference

27 February 2018

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

positive regulation of cholesterol storage

determination method

1 reference

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

cellular response to laminar fluid shear stress

determination method

1 reference

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

cellular response to starvation

determination method

1 reference

27 February 2018

Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

cholesterol metabolic process

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

negative regulation of transcription by RNA polymerase II

determination method

2 references

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

transcription, DNA-templated

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

regulation of autophagy of mitochondrion

determination method

1 reference

27 February 2018

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

negative regulation of cholesterol efflux

determination method

1 reference

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

27 February 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

27 February 2018

Expression of a novel, sterol-insensitive form of sterol regulatory element binding protein 2 (SREBP2) in male germ cells suggests important cell- and stage-specific functions for SREBP targets during spermatogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

regulation of cholesterol biosynthetic process

determination method

1 reference

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

cellular response to low-density lipoprotein particle stimulus

determination method

1 reference

27 February 2018

Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q12772&geneProductId=UniProtKB:Q12772

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000354476

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000354476

ENSP00000395728

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000395728

ENSP00000412287

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000412287

ENSP00000484441

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000484441

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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