Phosphoribosyl pyrophosphate synthetase 1 (Q21119240)

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mammalian protein found in Homo sapiens

PRS-I
deafness, X-linked 2, perceptive, congenital
ribose-phosphate pyrophosphokinase 1
PRPS1
phosphoribosyl pyrophosphate synthase I
PPRibP
dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1)
ribose-phosphate diphosphokinase 1
deafness 2, perceptive, congenital

Language	Label	Description	Also known as
English	Phosphoribosyl pyrophosphate synthetase 1	mammalian protein found in Homo sapiens	PRS-I deafness, X-linked 2, perceptive, congenital ribose-phosphate pyrophosphokinase 1 PRPS1 phosphoribosyl pyrophosphate synthase I PPRibP dJ1070B1.2 (phosphoribosyl pyrophosphate synthetase 1) ribose-phosphate diphosphokinase 1 deafness 2, perceptive, congenital

Statements

1 reference

13 November 2019

UniProt protein ID

Ribose-phosphate pyrophosphokinase, bacterial-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60891

Phosphoribosyltransferase-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60891

Phosphoribosyltransferase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ribose-phosphate pyrophosphokinase, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphoribosyl pyrophosphate synthetase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

ribose phosphate diphosphokinase activity

determination method

8 references

27 March 2018

Phosphoribosylpyrophosphate synthetase overactivity as a cause of uric acid overproduction in a young woman

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

27 March 2018

Arts syndrome is caused by loss-of-function mutations in PRPS1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

27 March 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

27 March 2018

Mutations in PRPS1, which encodes the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis, cause hereditary peripheral neuropathy with hearing loss and optic neuropathy (cmtx5)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

27 March 2018

Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

27 March 2018

Human phosphoribosylpyrophosphate synthetase. Distribution, purification, and properties

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

protein binding

determination method

4 references

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

magnesium ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

identical protein binding

determination method

3 references

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

carbohydrate binding

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

ribose phosphate diphosphokinase activity

determination method

8 references

1 January 2018

Phosphoribosylpyrophosphate synthetase overactivity as a cause of uric acid overproduction in a young woman

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

1 January 2018

Arts syndrome is caused by loss-of-function mutations in PRPS1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

1 January 2018

Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

1 January 2018

Mutations in PRPS1, which encodes the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis, cause hereditary peripheral neuropathy with hearing loss and optic neuropathy (cmtx5)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

1 January 2018

Human phosphoribosylpyrophosphate synthetase. Distribution, purification, and properties

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

8 April 2019

Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

ribose phosphate diphosphokinase activity

determination method

7 references

8 April 2019

Arts syndrome is caused by loss-of-function mutations in PRPS1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

8 April 2019

Phosphoribosylpyrophosphate synthetase overactivity as a cause of uric acid overproduction in a young woman

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

8 April 2019

Crystal structure of human phosphoribosylpyrophosphate synthetase 1 reveals a novel allosteric site

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

8 April 2019

Mutations in PRPS1, which encodes the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis, cause hereditary peripheral neuropathy with hearing loss and optic neuropathy (cmtx5)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

ribose phosphate diphosphokinase complex

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

protein-containing complex

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

ribose phosphate diphosphokinase complex

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

biological process

5-phosphoribose 1-diphosphate biosynthetic process

determination method

purine nucleotide biosynthetic process

determination method

1 reference

27 March 2018

Phosphoribosylpyrophosphate synthetase overactivity as a cause of uric acid overproduction in a young woman

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

nucleotide biosynthetic process

determination method

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

nervous system development

determination method

2 references

8 April 2019

Human X-linked phosphoribosylpyrophosphate synthetase superactivity is associated with distinct point mutations in the PRPS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

8 April 2019

Mutations in PRPS1, which encodes the phosphoribosyl pyrophosphate synthetase enzyme critical for nucleotide biosynthesis, cause hereditary peripheral neuropathy with hearing loss and optic neuropathy (cmtx5)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

ribonucleoside monophosphate biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

pyrimidine nucleotide biosynthetic process

determination method

1 reference

8 April 2019

Arts syndrome is caused by loss-of-function mutations in PRPS1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

hypoxanthine biosynthetic process

determination method

1 reference

8 April 2019

Arts syndrome is caused by loss-of-function mutations in PRPS1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

purine nucleobase metabolic process

determination method

1 reference

8 April 2019

Human X-linked phosphoribosylpyrophosphate synthetase superactivity is associated with distinct point mutations in the PRPS1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

cellular biosynthetic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

urate biosynthetic process

determination method

1 reference

8 April 2019

Phosphoribosylpyrophosphate synthetase overactivity as a cause of uric acid overproduction in a young woman

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

nucleoside metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P60891

determination method

AMP biosynthetic process

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

ribose phosphate metabolic process

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

animal organ regeneration

determination method

1 reference

27 March 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P60891&geneProductId=UniProtKB:P60891

determination method

5-phosphoribose 1-diphosphate biosynthetic process

determination method

nucleotide biosynthetic process

determination method

Phosphoribosyltransferase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60891

Ribose-phosphate pyrophosphokinase, N-terminal domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60891

Phosphoribosyl pyrophosphate synthetase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P60891

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000361512

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000361512

ENSP00000361495

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000361495

ENSP00000361496

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000361496

ENSP00000361505

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000361505

ENSP00000496286

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496286

ENSP00000495493

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495493

ENSP00000496554

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496554

ENSP00000495801

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000495801

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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